The DOI matches its Crossref record.
Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.
Open accessAbstract
Lymphocyte responsiveness in rats was found to depend on serum prolactin levels. Blocking pituitary prolactin release with bromocriptine severely reduces lymphocyte reactivity in vitro (mixed lymphocyte reaction) as well as in vivo (graft-versus-host reaction). In addition, evidence for a prolactin/growth hormone-related mRNA species produced in mitogen- and antigen-stimulated lymphocytes has been obtained. Prolactin was shown to compete in a dose-dependent fashion with the immunosuppressant cyclosporine (cyclosporin A) for a common binding site on the surface of T lymphocytes. Further, stimulation of prolactin secretion reversed the immunosuppression induced by cyclosporine. We conclude that prolactin is involved in the maintenance of T-cell immunocompetence and that the immunosuppressive effects of cyclosporine may be mediated by the displacement of prolactin from binding sites on lymphocytes.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Suppression of Macrophage Activation and T-Lymphocyte Function in Hypoprolactinemic Mice
Bernton, E. W., Meltzer, M. S., & Holaday, J. W. (1988) · Science · doi:10.1126/science.3122324 · Cited by 384
Clark, R. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.2.0296 · Cited by 314
Borba, V. V., Zandman-Goddard, G., & Shoenfeld, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00073 · Cited by 222
Metadata
- Authors
- Hiestand, P. C., Mekler, P., Nordmann, R., Grieder, A., & Permmongkol, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-04
- Volume
- 83
- Issue
- 8
- Pages
- 2599-2603
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999786335
- Cited by
- 242
- References
- 0
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. https://app.cochat.ai/papers/10.1073/pnas.83.8.2599
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- Hiestand, P. C., Mekler, P., Nordmann, R., Grieder, A., & Permmongkol, C. (1986). Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.8.2599
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
