Cited by 314Growth Hormone and Insulin-like Growth FactorsT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

The Somatogenic Hormones and Insulin-Like Growth Factor-1: Stimulators of Lymphopoiesis and Immune Function

Clark, Ross·1997·Endocrine Reviews

Abstract

I. Introduction II. Local GH Axis in Lymphoid Tissue A. Background: extrapituitary production? B. GH expression C. GH regulation D. GHRs E. GHR signaling III. GH Administration A. Effects on the thymus B. Pattern of GH exposure C. GH and immune function in humans IV. PRL A. PRL expression in lymphoid tissues B. PRL receptors C. Administration of PRL, anti-PRL antibodies, or bromocriptine V. Insulin-like Growth Factors A. Background B. IGF peptides C. Regulation of lymphocyte IGF-I D. IGF receptors on lymphocytes E. IGFBPs VI. Actions of IGF-I A. Bone marrow B. Effects on lymphoid organ size C. Effect of in vivo treatment on lymphocyte number and in vitro function D. Functional effects of IGF-I in vivo: antibody responses E. Immune reconstitution F. Mechanism of action: apoptosis VII. IGF-I in Different Physiological States A. IGF-I in pregnancy B. IGF-I in diabetes C. IGF-I in gastrointestinal disorders D. IGF-I action in polycythemia vera VIII. GH/IGF-I as Antistress Hormones IX. Therapeutic Potential X....

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Crossref · 10.1210/edrv.18.2.0296

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Authors
Clark, R.
Affiliations
Genentech (US)
Corresponding author
Clark, Ross
Venue
Endocrine Reviews
Published
1997-04-01
Volume
18
Issue
2
Pages
157-179
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W2131263920
Cited by
314
References
278
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 8 · 2012: 12
FWCI
3.47
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
growth hormone, insulin-like growth factor I, lymphocyte development, immune function, thymus, prolactin, growth hormone receptor, IGF receptors, IGF binding proteins, lymphocyte apoptosis, antibody response, immune reconstitution, pregnancy, diabetes mellitus, polycythemia vera, lymphoid tissue
MeSH terms
Animals, B-Lymphocytes, Diabetes Mellitus, Gastrointestinal Diseases, Humans, Hypothalamo-Hypophyseal System, Insulin-Like Growth Factor I, Lymphoid Tissue, Models, Biological, Receptors, Somatotropin, Growth Hormone, T-Lymphocytes, Thymus Gland, Signal Transduction, Insulin-Like Growth Factor Binding Proteins

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