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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
Open accessAbstract
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of membrane-spanning domains. While the protein is 87% identical overall with the previously cloned hamster beta 2-adrenergic receptor, the most highly conserved regions are the putative transmembrane helices (95% identical) and cytoplasmic loops (93% identical), suggesting that these regions of the molecule harbor important functional domains. Several of the transmembrane helices also share lesser degrees of identity with comparable regions of select members of the opsin family of visual pigments. We have localized the gene for the beta 2-adrenergic receptor to q31-q32 on chromosome 5. This is the same position recently determined for the gene encoding the receptor for platelet-derived growth factor and is adjacent to that for the FMS protooncogene, which encodes the receptor for the macrophage colony-stimulating factor.
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Cited by
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Eickelberg, O., Roth, M., Lörx, R., Bruce, V., Rüdiger, J., Johnson, M., & Block, L.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1005 · Cited by 378
Jahns, R., Boivin, V., Siegmund, C., Inselmann, G., Lohse, M. J., & Boege, F. (1999) · Circulation · doi:10.1161/01.cir.99.5.649 · Cited by 262
Metadata
- Authors
- Kobilka, B. K., Dixon, R. A., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., Yang-Feng, T. L., Francke, U., Caron, M. G., & Lefkowitz, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-01
- Volume
- 84
- Issue
- 1
- Pages
- 46-50
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966043663
- Cited by
- 679
- References
- 0
- FWCI
- 21.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. https://app.cochat.ai/papers/10.1073/pnas.84.1.46
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- Kobilka, B. K., Dixon, R. A., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., Yang-Feng, T. L., Francke, U., Caron, M. G., & Lefkowitz, R. J. (1987). cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.1.46
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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