The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.
Open accessAbstract
Blockade of Ca2+ channels by omega-conotoxin GVIA, a 27 amino acid peptide from the venom of the marine snail Conus geographus, was investigated with patch-clamp recordings of whole-cell and unitary currents in a variety of cell types. In dorsal root ganglion neurons, the toxin produces persistent block of L- and N-type Ca2+ channels but only transiently inhibits T-type channels. Its actions appear to be neuron-specific, since it blocks high-threshold Ca2+ channels in sensory, sympathetic, and hippocampal neurons of vertebrates but not in cardiac, skeletal, or smooth muscle cells. Block occurs through direct interaction of the toxin with an external site closely associated with the Ca2+ channel, without apparent involvement of a second messenger or dependence on channel gating. The tissue and channel-type specificity and the directness and slow reversibility of the block are features that favor use of omega-conotoxin as a tool for purifying particular neuronal Ca2+ channels and defining their physiological function.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons
Hirning, L. D., Fox, A. P., McCleskey, E. W., Olivera, B. M., Thayer, S. A., Miller, R. J., & Tsien, R. W. (1988) · Science · doi:10.1126/science.2447647 · Cited by 853
Self-citationα-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., & Südhof, T. C. (2003) · Nature · doi:10.1038/nature01755 · Cited by 699
Oliveria, S. F., Dell'Acqua, M. L., & Sather, W. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.032 · Cited by 344
Metadata
- Authors
- McCleskey, E. W., Fox, A. P., Feldman, D. H., Cruz, L. J., Olivera, B. M., Tsien, R. W., & Yoshikami, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-06
- Volume
- 84
- Issue
- 12
- Pages
- 4327-4331
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033558463
- Cited by
- 764
- References
- 1
- FWCI
- 21.00
- Type
- journal article
- Language
- en
- Open access
- green
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- McCleskey, E. W., Fox, A. P., Feldman, D. H., Cruz, L. J., Olivera, B. M., Tsien, R. W., & Yoshikami, D. (1987). Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.12.4327
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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