Astrocyte gene expression in Creutzfeldt-Jakob disease
Open accessAbstract
Gliosis (hyperplasia and hypertrophy of astrocytes), the fundamental response of the central nervous system to tissue destruction, typically becomes apparent only several weeks after injury. The biochemical hallmark of this response is a marked accumulation of the specific astrocyte intermediate filament glial fibrillary acidic protein (GFAP). To date despite its importance, the mechanisms of GFAP gene regulation have not been studied in any developmental or pathological system to our knowledge, and the molecular signals for GFAP mRNA and protein accumulation are not defined. In Creutzfeldt-Jakob disease, a progressive dementing illness caused by an "unconventional agent," we find steadily increasing elevations of GFAP mRNA throughout the later stages of disease, using two independent GFAP cDNA clones, representing the entire insert or the 3'-noncoding region (pScr-1). The accumulation of GFAP, assessed immunocytochemically, follows GFAP mRNA elevation. A 5-fold stimulation of GFAP gene expression precedes the development of florid histologic lesions in the cerebrum, and in the cerebellum 5- to 6-fold increases occurred with no detectable spongiform changes at any time during disease. Therefore, these GFAP changes cannot be simply a response to neuronal damage. These effects are directly or indirectly caused by high local concentrations of agent and possibly involve a humoral factor.
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- Authors
- Manuelidis, L., Tesin, D. M., Sklaviadis, T., & Manuelidis, E. E.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1987-08
- Volume
- 84
- Issue
- 16
- Pages
- 5937-5941
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC298978
- OpenAlex
- W1983059514
- Cited by
- 77
- References
- 26
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2014: 2 · 2012: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 03106)
- National Institute of Neurological Disorders and Stroke (NS12674)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Creutzfeldt-Jakob disease, glial fibrillary acidic protein, astrocytes, gliosis, prion disease, cerebellum, cerebrum, humoral factors
- MeSH terms
- Animals, Astrocytes, Base Sequence, DNA, DNA Restriction Enzymes, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Cricetinae, Creutzfeldt-Jakob Syndrome, Nucleic Acid Hybridization, RNA, RNA, Messenger
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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