The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.
Open accessAbstract
A family of genes coding for proteins homologous to the alpha subunit of the muscle nicotinic acetylcholine receptor has been identified in the rat genome. These genes are transcribed in the central and peripheral nervous systems in areas known to contain functional nicotinic receptors. In this paper, we demonstrate that three of these genes, which we call alpha 3, alpha 4, and beta 2, encode proteins that form functional nicotinic acetylcholine receptors when expressed in Xenopus oocytes. Oocytes expressing either alpha 3 or alpha 4 protein in combination with the beta 2 protein produced a strong response to acetylcholine. Oocytes expressing only the alpha 4 protein gave a weak response to acetylcholine. These receptors are activated by acetylcholine and nicotine and are blocked by Bungarus toxin 3.1. They are not blocked by alpha-bungarotoxin, which blocks the muscle nicotinic acetylcholine receptor. Thus, the receptors formed by the alpha 3, alpha 4, and beta 2 subunits are pharmacologically similar to the ganglionic-type neuronal nicotinic acetylcholine receptor. These results indicate that the alpha 3, alpha 4, and beta 2 genes encode functional nicotinic acetylcholine receptor subunits that are expressed in the brain and peripheral nervous system.
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Cites
A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014393 · Cited by 812
Cited by
Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes
Boulter, J., Hollmann, M., O'Shea-Greenfield, A., Hartley, M., Deneris, E., Maron, C., & Heinemann, S. (1990) · Science · doi:10.1126/science.2168579 · Cited by 938
Self-citationLuetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558
Self-citationNicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551
Self-citationSchoepfer, R., Conroy, W. G., Whiting, P., Gore, M., & Lindstrom, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90031-a · Cited by 473
PICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 460
Metadata
- Authors
- Boulter, J., Connolly, J., Deneris, E., Goldman, D., Heinemann, S., & Patrick, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-11
- Volume
- 84
- Issue
- 21
- Pages
- 7763-7767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1995971676
- Cited by
- 430
- References
- 1
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Boulter, J., Connolly, J., Deneris, E., Goldman, D., Heinemann, S., & Patrick, J. (1987). Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.21.7763
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
