The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes
Abstract
Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate. The proteins encoded by the individual genes form homomeric ion channels in Xenopus oocytes that are sensitive to glutamatergic agonists such as kainate and quisqualate but not to N -methyl-D-aspartate, indicating that binding sites for kainate and quisqualate exist on single receptor polypeptides. In addition, kainate-evoked conductances are potentiated in oocytes expressing two or more of the cloned receptor subunits. Electrophysiological responses obtained with certain subunit combinations show agonist profiles and current-voltage relations that are similar to those obtained in vivo. Finally, in situ hybridization histochemistry reveals that these genes are transcribed in shared neuroanatomical loci. Thus, as with γ-aminobutyric acid, glycine, and nicotinic acetylcholine receptors, native kainate-quisqualate-sensitive glutamate receptors form a family of heteromeric proteins.
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Cites
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Cited by
The Glutamate Receptor Ion Channels
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Heteromeric NMDA receptors: molecular and functional distinction of subtypes
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Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543
Molecular cloning and characterization of the rat NMDA receptor
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
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Metadata
- Authors
- Boulter, J., Hollmann, M., O'Shea-Greenfield, A., Hartley, M., Deneris, E., Maron, C., & Heinemann, S.
- Venue
- Science
- Published
- 1990-08-31
- Volume
- 249
- Issue
- 4972
- Pages
- 1033-1037
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966681799
- Cited by
- 938
- References
- 41
- FWCI
- 36.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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