A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793 · see citing works

Transcription termination and 3′ processing: the end is in site!

Birnstiel, M. L., Busslinger, M., & Strub, K. (1985) · Cell · doi:10.1016/s0092-8674(85)80007-6 · Cited by 1,477 · see citing works

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

Kafatos, F. C., Jones, C. W., & Efstratiadis, A. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1541 · Cited by 1,397 · see citing works

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

Gunning, P. W., Ponte, P. A., Okayama, H., Engel, J. N., Blau, H. M., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.5.787-795.1983 · Cited by 1,200 · see citing works

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

Early, P. (1980) · Cell · doi:10.1016/0092-8674(80)90617-0 · Cited by 890 · see citing works

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

Bentley, D. L., & Groudine, M. T. (1986) · Nature · doi:10.1038/321702a0 · Cited by 841 · see citing works

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

Jones, N. C., & Shenk, T. E. (1979) · Cell · doi:10.1016/0092-8674(79)90275-7 · Cited by 784 · see citing works

Variety in the level of gene control in eukaryotic cells

Darnell, J. E., Jr. (1982) · Nature · doi:10.1038/297365a0 · Cited by 772 · see citing works

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

Zoller, M. J., & Smith, M. J. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.20.6487 · Cited by 762 · see citing works

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

Nevins, J. R., & Darnell, J. E., Jr. (1978) · Cell · doi:10.1016/0092-8674(78)90071-5 · Cited by 470 · see citing works

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

Hearing, P., & Shenk, T. E. (1983) · Cell · doi:10.1016/0092-8674(83)90012-0 · Cited by 466 · see citing works

The sequence of the chromosomal mouse β-globin major gene: Homologies in capping, splicing and poly(A) sites

Konkel, D. A., Tilghman, S. M., & Leder, P. (1978) · Cell · doi:10.1016/0092-8674(78)90040-5 · Cited by 406 · see citing works

The primary transcription unit of the mouse β-Major globin gene

Hofer, E., & Darnell, J. E., Jr. (1981) · Cell · doi:10.1016/0092-8674(81)90154-9 · Cited by 356 · see citing works

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

Weintraub, H. M., Larsen, A. S., & Groudine, M. T. (1981) · Cell · doi:10.1016/0092-8674(81)90323-8 · Cited by 341 · see citing works

Accurate cleavage and polyadenylation of exogenous RNA substrate

Moore, C. L., & Sharp, P. A. (1985) · Cell · doi:10.1016/s0092-8674(85)80065-9 · Cited by 335 · see citing works

Intragenic pausing and anti‐sense transcription within the murine c‐myc locus.

Nepveu, A., & Marcu, K. B. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04580.x · Cited by 326 · see citing works

Evolutionary history of a multigene family: An expressed human β-tubulin gene and three processed pseudogenes

Lee, M. G.-S., Lewis, S. A., Wilde, C. D., et al. (1983) · Cell · doi:10.1016/0092-8674(83)90429-4 · Cited by 283 · see citing works

Formation of the 3′ end of U1 snRNA requires compatible snRNA promoter elements

Hernandez, N., & Weiner, A. M. (1986) · Cell · doi:10.1016/0092-8674(86)90447-2 · Cited by 256 · see citing works

Alpha‐thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human alpha 2 globin gene.

Whitelaw, E., & Proudfoot, N. J. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04587.x · Cited by 237 · see citing works

3′ end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters

de Vegvar, H. E. N., Lund, E., & Dahlberg, J. E. (1986) · Cell · doi:10.1016/0092-8674(86)90448-4 · Cited by 227 · see citing works

Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences.

Tilghman, S. M., Tiemeier, D. C., Polsky, F. I., Edgell, M. H., Seidman, J. G., Leder, A., Enquist, L. W., Norman, B., & Leder, P. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4406 · Cited by 226 · see citing works

Site-specific polyadenylation in a cell-free reaction

Moore, C. L., & Sharp, P. A. (1984) · Cell · doi:10.1016/0092-8674(84)90337-4 · Cited by 224 · see citing works

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection

Logan, J., & Shenk, T. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3655 · Cited by 198 · see citing works

Factors involved in specific transcription by mammalian RNA polymerase II. Transcription factor IIS stimulates elongation of RNA chains.

Reinberg, D., & Roeder, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61507-8 · Cited by 163 · see citing works

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

Nelson, K. J., Haimovich, J., & Perry, R. P. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.7.1317 · Cited by 162 · see citing works

The addition of 5′ cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped

Salditt-Georgieff, M., Harpold, M. M., Chen‐Kiang, S., et al. (1980) · Cell · doi:10.1016/0092-8674(80)90389-x · Cited by 161 · see citing works

Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site

Grayhack, E. J., YANG, X., Lau, L. F., et al. (1985) · Cell · doi:10.1016/s0092-8674(85)80121-5 · Cited by 153 · see citing works

Mode of regulation of immunoglobulin μ- and δ-chain expression varies during B-lymphocyte maturation

Mather, E. L., Nelson, K. J., Haimovich, J., et al. (1984) · Cell · doi:10.1016/0092-8674(84)90226-5 · Cited by 146 · see citing works

3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

Birchmeier, C., Schümperli, D., Sconzo, G., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.4.1057 · Cited by 143 · see citing works

The major late adenovirus type-2 transcription unit: Termination is downstream from the last poly(A) site

Fraser, N., Nevins, J. R., Ziff, E. B., et al. (1979) · Journal of Molecular Biology · doi:10.1016/0022-2836(79)90474-1 · Cited by 140 · see citing works

Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters.

Smale, S. T., & Tjian, R. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.2.352 · Cited by 134 · see citing works

Globin RNA transcription: A possible termination site and demonstration of transcriptional control correlated with altered chromatin structure

Hofer, E., Hofer-Warbinek, R., & Darnell, J. E., Jr. (1982) · Cell · doi:10.1016/0092-8674(82)90450-0 · Cited by 133 · see citing works

Termination of transcription in the mouse α-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site

Hagenbüchle, O., Wellauer, P. K., Cribbs, D. L., et al. (1984) · Cell · doi:10.1016/0092-8674(84)90269-1 · Cited by 129 · see citing works

Physical mapping of a large-plaque mutation of adenovirus type 2

Chinnadurai, G., Chinnadurai, S., & Brusca, J. S. (1979) · Journal of Virology · doi:10.1128/jvi.32.2.623-628.1979 · Cited by 127 · see citing works

[70] Definition and mapping of adenovirus 2 nuclear transcription

Nevins, J. R. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65072-1 · Cited by 121 · see citing works

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.Preprint

Galli, G., Guise, J. W., McDevitt, M. A., et al. (1987) · Genes & Development · doi:10.1101/gad.1.5.471 · Cited by 110 · see citing works

Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse β-major globin terminator element

Falck-Pedersen, E., Logan, J. S., Shenk, T. E., et al. (1985) · Cell · doi:10.1016/0092-8674(85)90349-6 · Cited by 109 · see citing works

Control of messenger RNA concentration by differential cytoplasmic half-life

Wilson, M. C., & Darnell, J. E., Jr. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90537-4 · Cited by 99 · see citing works

Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse β-globin (major) gene

Citron, B. A., Falck-Pedersen, E., Salditt-Georgieff, M., et al. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.22.8723 · Cited by 96 · see citing works

Purification and functional characterization of transcription factor SII from calf thymus. Role in RNA polymerase II elongation.

Rappaport, J., Reinberg, D., Zandomeni, R. O., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61178-0 · Cited by 90 · see citing works

A Specific DNA Sequence Controls Termination of Transcription in the Gastrin Gene

Sato, K., Ito, R., Baek, K., & Agarwal, K. L. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1032 · Cited by 87 · see citing works

Premature termination during adenovirus transcription

Evans, R. M., WEBER, J., Ziff, E. B., et al. (1979) · Nature · doi:10.1038/278367a0 · Cited by 82 · see citing works

The phage λ Q gene product: Activity of a transcription antiterminator in vitro

Grayhack, E. J., & Roberts, J. W. (1982) · Cell · doi:10.1016/0092-8674(82)90260-4 · Cited by 79 · see citing works

Transcription of the Mouse Dihydrofolate Reductase Gene Proceeds Unabated Through Seven Polyadenylation Sites and Terminates Near a Region of Repeated DNA

Frayne, E. G., Leys, E. J., Crouse, G. F., et al. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.12.2921-2924.1984 · Cited by 63 · see citing works

Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unit

Chen‐Kiang, S., Wolgemuth, D. J., Hsu, M., et al. (1982) · Cell · doi:10.1016/0092-8674(82)90212-4 · Cited by 63 · see citing works

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μm and μs mRNA

Nelson, K. J., Haimovich, J., & Perry, R. P. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.7.1317-1332.1983 · Cited by 63 · see citing works

Termination of the ovalbumin gene transcription.

LeMeur, M., Galliot, B., & GERLINGER, P. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02209.x · Cited by 62 · see citing works

Transcription of Herpes Simplex Virus tk Sequences Under the Control of Wild-Type and Mutant Human RNA Polymerase I Promoters

Smale, S. T., & Tjian, R. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.2.352-362.1985 · Cited by 57 · see citing works

Induced transcription of the mouse β-globintranscription unit in erythroleukemia cells

Salditt-Georgieff, M., Sheffery, M., Krauter, K. S., et al. (1984) · Journal of Molecular Biology · doi:10.1016/s0022-2836(84)80016-9 · Cited by 46 · see citing works

A Specific DNA Sequence Controls Termination of Transcription in the Gastrin Gene

Sato, K., Ito, R., Baek, K., et al. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1032-1043.1986 · Cited by 46 · see citing works

RNA polymerase II transcription terminates at a specific DNA sequence in a HeLa cell-free reaction.

Baek, K., Sato, K., Ito, R., et al. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7623 · Cited by 42 · see citing works

Transcription unit mapping in adenovirus: regions of termination

Iwamoto, S., Eggerding, F. A., FALCK-PEDERSON, E., et al. (1986) · Journal of Virology · doi:10.1128/jvi.59.1.112-119.1986 · Cited by 37 · see citing works

Coupling mRNA processing with transcription in time and space

Bentley, D. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3662 · Cited by 828 · see citing works

Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition

Fong, N., Brannan, K., Erickson, B., Kim, H., Cortazar, M. A., Sheridan, R. M., Nguyen, T., Karp, S., & Bentley, D. L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.026 · Cited by 217 · see citing works

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism

Cortazar, M. A., Sheridan, R. M., Erickson, B., Fong, N., Glover-Cutter, K., Brannan, K., & Bentley, D. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.031 · Cited by 227 · see citing works

RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

Muniz, L., Nicolas, E., & Trouche, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020105740 · Cited by 203 · see citing works

Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination

Huang, K.-L., Jee, D., Stein, C. B., Elrod, N. D., Henriques, T., Mascibroda, L. G., Baillat, D., Russell, W. K., Adelman, K., & Wagner, E. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.08.016 · Cited by 184 · see citing works

Genetic predisposition in alcoholism: Association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics

Blum, K., Noble, E. P., Sheridan, P. J., Montgomery, A., Ritchie, T., Ozkaragoz, T., Fitch, R. J., Wood, R., Finley, O., & Sadlack, F. (1993) · Alcohol · doi:10.1016/0741-8329(93)90054-r · Cited by 123 · see citing works

DNA-directed termination of RNA polymerase II transcription

Han, Z., Moore, G. A., Mitter, R., Martínez, D. L., Wan, L., Dirac-Svejstrup, A. B., Rueda, D., & Svejstrup, J. Q. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.08.007 · Cited by 47 · see citing works

RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway

Collin, P., Jerónimo, C., Poitras, C., & Robert, F. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.002 · Cited by 49 · see citing works

Promoter melting triggered by bacterial RNA polymerase occurs in three steps

Chen, J., Darst, S. A., & Thirumalai, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003533107 · Cited by 67 · see citing works

Transcription termination in Escherichia coli

Arndt, K. M., & Chamberlin, M. J. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90457-3 · Cited by 53 · see citing works

The Evolutionarily Conserved Pol II Flap Loop Contributes to Proper Transcription Termination on Short Yeast Genes

Pearson, E. L., & Moore, C. L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.007 · Cited by 15 · see citing works