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Cited by 314

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

Open access
Davis, M G, Kenney, S C, Kamine, J, Pagano, J S, Huang, E S·1987·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.84.23.8642
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Abstract

Almost all homosexual patients with acquired immunodeficiency syndrome are also actively infected with human cytomegalovirus (HCMV). We have hypothesized that an interaction between HCMV and human immunodeficiency virus (HIV), the agent that causes acquired immunodeficiency syndrome, may exist at a molecular level and contribute to the manifestations of HIV infection. In this report, we demonstrate that the immediate-early gene region of HCMV, in particular immediate-early region 2, trans-activates the expression of the bacterial gene chloramphenicol acetyltransferase that is fused to the HIV long terminal repeat and carried by plasmid pHIV-CAT. The HCMV immediate-early trans-activator increases the level of mRNA from the plasmid pHIV-CAT. The sequences of HIV that are responsive to trans-activation by the HCMV immediate-early region are distinct from HIV sequences that required for response to the HIV tat. The stimulation of HIV gene expression by HCMV gene functions could enhance the consequences of HIV infection in persons with previous or concurrent HCMV infection.

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Metadata

Authors
Davis, M. G., Kenney, S. C., Kamine, J., Pagano, J. S., & Huang, E. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1987-12
Volume
84
Issue
23
Pages
8642-8646
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.84.23.8642
OpenAlex
W2052573307
Cited by
314
References
15
FWCI
30.87
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. https://app.cochat.ai/papers/10.1073/pnas.84.23.8642
The paper
Davis, M. G., Kenney, S. C., Kamine, J., Pagano, J. S., & Huang, E. S. (1987). Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.23.8642

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.