The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.
Open accessAbstract
Four monoclonal anti-DNA antibodies derived from a single autoimmune MRL/lpr mouse were studied. Three of these antibodies showed similarities in DNA binding; the fourth had a much higher specific activity for single-stranded DNA and, in addition, was unique in binding double-stranded DNA and cardiolipin. Complete nucleotide sequences of heavy- and light-chain variable regions demonstrated that all four antibodies are clonally related. The sequences also showed numerous somatic mutations, the distribution of which suggests that positive selection by antigen operated on these clonally related autoantibodies.
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Citations
Cites
Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus
Arana, R., & Seligmann, M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105677 · Cited by 158
Cited by
Moreth, K., Brodbeck, R., Babelova, A., Gretz, N., Spieker, T., Zeng-Brouwers, J., Pfeilschifter, J., Young, M. F., Schaefer, R. M., & Schaefer, L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42213 · Cited by 207
Dugan, H. L., Stamper, C. T., Li, L., Changrob, S., Asby, N. W., Halfmann, P. J., Zheng, N.-Y., Huang, M., Shaw, D. G., Cobb, M. S., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.001 · Cited by 134
Garza, R., Marchioni, J. M., Honeycutt, J. D., Hurlburt, N. K., Torres, C., Garcia, A., Neog, S., Loranc, E., Yemington, E., Towers, D., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052979 · Cited by 1
Metadata
- Authors
- Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., & Weigert, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 24
- Pages
- 9150-9154
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978648487
- Cited by
- 462
- References
- 1
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., & Weigert, M. G. (1987). Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.24.9150
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
