The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus
Open accessAbstract
The relative reactivities with native and denatured DNA of 35 lupus sera were investigated by quantitative complement fixation and precipitin studies and showed great variations. The use of purified native DNA demonstrated that, in at least 22 of these 35 sera, the anti-DNA antibodies reacted with the native form, independently of denatured contaminants. Systemic lupus sera were shown to contain three main types of DNA antibodies: those reacting only with denatured DNA, those reacting to the same extent with both forms of DNA, and those reacting preferentially with native DNA. In some instances, the latter antibodies fix complement and precipitate only with native DNA but are inhibited by the denatured form. This finding points to the importance of conformation in the antigenic structure of DNA. The simultaneous occurrence of different varieties of DNA antibodies was demonstrated in several sera. Evidence was obtained that some of these human antibodies to DNA can belong to the IgM class. Thus, DNA antibodies from systemic lupus patients differ in many respects from most of the experimentally produced antibodies capable of reacting with DNA.
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“Many test methods are available and anti-dsDNA tests, by design, detect different subpopulations of anti-dsDNA with distinct fine specificities (16,20,(22)(23)(24).”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [16]
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Cites
Immunochemical quantitation of antigens by single radial immunodiffusion
Mancini, G., Carbonara, A. O., & Heremans, J. F. (1965) · Immunochemistry · doi:10.1016/0019-2791(65)90004-2 · Cited by 9,139
A fractionating column for analysis of nucleic acids
Mandell, J. D., & Hershey, A. D. (1960) · Analytical Biochemistry · doi:10.1016/0003-2697(60)90020-8 · Cited by 1,403
Tan, E. M., Schur, P. H., Carr, R. I., & Kunkel, H. G. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105479 · Cited by 845
Wasserman, E., & Levine, L. (1961) · The Journal of Immunology · doi:10.4049/jimmunol.87.3.290 · Cited by 653
Immunochemical quantitation of antigens by single radial immunodiffusion
Mancini, G. (1965) · Molecular Immunology · doi:10.1016/0161-5890(65)90004-0 · Cited by 470
ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES AND RIBONUCLEOTIDES AND THEIR REACTION WITH DNA
Erlanger, B. F., & Beiser, S. M. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.1.68 · Cited by 447
Complement fixation with cell nuclei and DNA in lupus erythematosus
Robbins, W. C., Holman, H. R., Deicher, H., & Kunkel, H. G. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23545 · Cited by 302
A DNA-Reacting Factor in Serum of a Patient with Lupus Erythematosus Diffusus.
Ceppellini, R., Polli, E., & Celada, F. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23544 · Cited by 249
PRODUCTION OF ANTIBODIES TO DENATURED DEOXYRIBONUCLEIC ACID (DNA)
Plescia, O. J., Braun, W. H., & Palczuk, N. C. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.2.279 · Cited by 247
The Nature of an Antigenic Determinant
Kabat, E. A. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.97.1.1 · Cited by 218
Research works printed but not linked: 2
- Butler, V. P., S. M. Beiser, B. F. Erlanger, S. W. Tanenbaum, S. Cohen, and A. Bendich. 1962. Pu- rine-specific antibodies which react with deoxyri- bonucleic acid (DNA). Proc. NatI. Acad. Sci. 48: 1597.
- Tanenbaum, S. W., and S. M. Beiser. 1963. Py- rimidine-specific antibodies which react with de- oxyribonucleic acid (DNA). Proc. NatI. Acad. Sci. 49: 662.
Cited by
Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine
Tan, E. M. (1982) · Advances in Immunology · doi:10.1016/s0065-2776(08)60836-6 · Cited by 965
Immune Complex Disease in Experimental Animals and Man
Cochrane, C. G., & Koffler, D. (1973) · Advances in Immunology · doi:10.1016/s0065-2776(08)60298-9 · Cited by 610
ANTIBODIES TO POLYNUCLEOTIDES IN HUMAN SERA: ANTIGENIC SPECIFICITY AND RELATION TO DISEASE
Koffler, D., Carr, R., Agnello, V., Thoburn, R., & Kunkel, H. G. (1971) · The Journal of Experimental Medicine · doi:10.1084/jem.134.1.294 · Cited by 510
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.
Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., & Weigert, M. G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9150 · Cited by 462
Wold, R. T., Young, F. E., Tan, E. M., & Farr, R. S. (1968) · Science · doi:10.1126/science.161.3843.806 · Cited by 378
Metadata
- Authors
- Arana, R., & Seligmann, M.
- Affiliations
- Université Paris Cité (FR)
- Venue
- Journal of Clinical Investigation
- Published
- 1967-11-01
- Volume
- 46
- Issue
- 11
- Pages
- 1867-1882
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292937
- OpenAlex
- W1968947138
- Cited by
- 158
- References
- 42
- Citations by year
- 2021: 1 · 2018: 3 · 2015: 1
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- systemic lupus erythematosus, anti-DNA antibodies, native DNA, denatured DNA, DNA conformation, antigenic structure, IgM, complement fixation, precipitating antibodies, antibody heterogeneity
- MeSH terms
- Antibodies, Complement Fixation Tests, DNA, Humans, Lupus Erythematosus, Systemic
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- CoChat. (2026). Citation check: Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus. https://app.cochat.ai/papers/10.1172/jci105677
- The paper
- Arana, R., & Seligmann, M. (1967). Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus. Journal of Clinical Investigation. https://doi.org/10.1172/jci105677
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
