The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.
Open accessAbstract
The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections. Using these assays we show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors. Tumor specimens have also been analyzed for the presence of mRNAs for the estrogen receptor and for the ERBB2 oncogene. No evidence for the presence of truncated forms of estrogen-receptor mRNA has been found, and overexpression of the ERBB2 oncogene did not correlate with the steroid receptor status or pS2 gene expression.
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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
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Self-citationMonoclonal antibodies localize oestrogen receptor in the nuclei of target cells
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Self-citationCloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line
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Self-citationEstablishment and characterization of a cell line of human breast carcinoma origin
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Cited by
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ERBB2 oncogene in human breast cancer and its clinical significance
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The role of Sp1 and Sp3 in normal and cancer cell biology
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Metadata
- Authors
- Rio, M. C., Bellocq, J. P., Gairard, B., Rasmussen, U. B., Krust, A., Koehl, C., Calderoli, H., Schiff, V, Renaud, R., & Chambon, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 24
- Pages
- 9243-9247
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2034687052
- Cited by
- 278
- References
- 14
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. https://app.cochat.ai/papers/10.1073/pnas.84.24.9243
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- Rio, M. C., Bellocq, J. P., Gairard, B., Rasmussen, U. B., Krust, A., Koehl, C., Calderoli, H., Schiff, V, Renaud, R., & Chambon, P. (1987). Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.24.9243
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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