The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.
Open accessAbstract
We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous.
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Cited by
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Metadata
- Authors
- van de Vijver, M., van de Bersselaar, R., Devilee, P., Cornelisse, C., Peterse, J., & Nusse, R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1987-05
- Volume
- 7
- Issue
- 5
- Pages
- 2019-2023
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1807228574
- Cited by
- 330
- References
- 40
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. https://app.cochat.ai/papers/10.1128/mcb.7.5.2019
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- van de Vijver, M., van de Bersselaar, R., Devilee, P., Cornelisse, C., Peterse, J., & Nusse, R. (1987). Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.7.5.2019
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