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Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas

Dürst, M, Croce, C M, Gissmann, L, Schwarz, E, Huebner, K·1987·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.84.4.1070
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Abstract

The chromosomal locations of cellular sequences flanking integrated papillomavirus DNA in four cervical carcinoma cell lines and a primary cervical carcinoma have been determined. The two human papillomavirus (HPV) 16 flanking sequences derived from the tumor were localized to chromosome regions 20pter----20q13 and 3p25----3qter, regions that also contain the protooncogenes c-src-1 and c-raf-1, respectively. The HPV 16 integration site in the SiHa cervical carcinoma-derived cell line is in chromosome region 13q14----13q32. The HPV 18 integration site in SW756 cervical carcinoma cells is in chromosome 12 but is not closely linked to the Ki-ras2 gene. Finally, in two cervical carcinoma cell lines, HeLa and C4-I, HPV 18 DNA is integrated in chromosome 8, 5' of the c-myc gene. The HeLa HPV 18 integration site is within 40 kilobases 5' of the c-myc gene, inside the HL60 amplification unit surrounding and including the c-myc gene. Additionally, steady-state levels of c-myc mRNA are elevated in HeLa and C4-I cells relative to other cervical carcinoma cell lines. Thus, in at least some genital tumors, cis-activation of cellular oncogenes by HPV may be involved in malignant transformation of cervical cells.

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Research works printed but not linked: 19

  1. [1]Dürst, M., Gissmann, L., Ikenberg, H. & zur Hausen, H. (1983) Proc. Natl. Acad. Sci. USA 80, 3812–3815. zur Hausen, H. (1977) Curr. Top. Microbiol. Immunol. 78, 1-30.
  2. [8]Dürst, M., Schwarz, E. & Gissmann, L. (1986) in Viral Etiology of Cervical Cancer, Banbury Report 21, eds. Peto, R. & zur Hausen, H. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY), pp. 273–280.
  3. [10]Schwarz, E., Schneider-Gädicke, A., Roggenbuck, B., Mayer, W., Gissmann, L. & zur Hausen, H. (1986) in Viral Etiology of Cervical Cancer, Banbury Report 21, eds. Peto, R. & zur Hausen, H. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY), pp. 281–290.
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  5. [11]Schwarz, E. & Schneider-Gädicke, A. (1986) in Herpes and Papillomaviruses, eds. DePalo, G., Rilke, F. & zur Hasen, H. (Serono Symposia Publications, Raven, New York), Vol. 31, pp. 105-114.
  6. [13]Isobe, M., Huebner, K., Erikson, J., Peterson, R. C., Bollum, F. J., Chang, L. M. S. & Croce, C. M. (1985) Proc. Natl. Acad. Sci. USA 82, 5836–5840.
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  11. [25]Cannizzaro, L. A., Croce, C. M., Griffen, C. A., Simeone, A., Boncinelli, E. & Huebner, K., Am. J. Hum. Genet., in press.
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Metadata

Authors
Dürst, M., Croce, C. M., Gissmann, L., Schwarz, E., & Huebner, K.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1987-02
Volume
84
Issue
4
Pages
1070-1074
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.84.4.1070
Cited by
232
References
2
Language
en

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