The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.
Open accessAbstract
cDNA clones encoding proteolipid protein (PLP) were isolated from a mouse brain library and sequenced. We describe two transcripts arising from the PLP locus by alternative splicing: the major one encodes the 277-amino acid PLP protein and the minor one corresponds to the DM-20 protein, a PLP-like protein of 20,000 Mr that shares both amino and carboxyl regions with PLP. These two transcripts lack approximately 70 bases in PLP mRNA from the dysmyelinating jimpy mutant. The deletion spans amino acids 208-232; however, this region is present in the jimpy PLP-encoding gene. We propose that the jimpy mutant suffers a point mutation or the deletion of a few bases in the PLP gene that alters the normal splicing pattern and generates partially deleted PLP transcripts.
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ROACH, A., TAKAHASHI, N., PRAVTCHEVA, D., RUDDLE, F., & HOOD, L. (1985) · Cell · doi:10.1016/s0092-8674(85)80110-0 · Cited by 336
Molineaux, S. M., Engh, H., de Ferra, F., Hudson, L., & Lazzarini, R. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7542 · Cited by 141
Self-citation
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Snipes, G., Suter, U., Welcher, A., & Shooter, E. (1992) · The Journal of cell biology · doi:10.1083/jcb.117.1.225 · Cited by 422
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Ye, P., Carson, J., & D'Ercole, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07344.1995 · Cited by 265
Metadata
- Authors
- Hudson, L. D., Berndt, J. A., Puckett, C., Kozak, C. A., & Lazzarini, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-03
- Volume
- 84
- Issue
- 5
- Pages
- 1454-1458
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000597403
- Cited by
- 174
- References
- 2
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Hudson, L. D., Berndt, J. A., Puckett, C., Kozak, C. A., & Lazzarini, R. A. (1987). Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.5.1454
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