Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice
Abstract
The gene for mouse myelin basic protein (MBP) was mapped to chromosome 18 by hybridization of cloned MBP probes to DNA from hamster-mouse hybrid cell lines, showing it to be linked to the shiverer mutation which causes abnormal CNS myelination. Genomic blotting experiments show that in the mutants five of six exons which constitute the wild-type gene have been deleted. In shiverer brains the steady state level of transcripts that initiate correctly at the 5' end of the remaining exon 1 is reduced 16-fold. These RNAs are not spliced correctly and are not efficiently polyadenylated. It is proposed that the partial deletion of the MBP gene is an important part of the shiverer lesion.
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Diffusion anisotropy is present even when compact myelin is completely absent, although it is significantly reduced.
“Indeed, diffusion anisotropy is present even when compact myelin is completely absent, although it is significantly reduced (Roach et al., 1985; Watanabe et al., 2010).”
From The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains (2017) · cites this paper as Roach et al., 1985
Cites
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245 · see citing works
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 14,678 · see citing works
Rigby, P. W. J., Dieckmann, M., Rhodes, C., & Berg, P. R. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90052-3 · Cited by 11,400 · see citing works
A general method for isolation of high molecular weight DNA from eukaryotes
Blin, N., & Stafford, D. W. (1976) · Nucleic Acids Research · doi:10.1093/nar/3.9.2303 · Cited by 2,812 · see citing works
Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene
McKnight, S. L., & Kingsbury, R. (1982) · Science · doi:10.1126/science.6283634 · Cited by 1,398 · see citing works
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis
Bailey, J. M., & Davidson, N. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80049-8 · Cited by 1,311 · see citing works
Favaloro, J. M., Treisman, R., & Kamen, R. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65070-8 · Cited by 1,292 · see citing works
Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes
Treisman, R., Orkin, S. H., & Maniatis, T. (1983) · Nature · doi:10.1038/302591a0 · Cited by 614 · see citing works
Dierks, P. M., van Ooyen, A., Cochran, M. D., Dobkin, C., Reiser, J., & Weissmann, C. (1983) · Cell · doi:10.1016/0092-8674(83)90055-7 · Cited by 562 · see citing works
Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin
Lemke, G., & Axel, R. (1985) · Cell · doi:10.1016/0092-8674(85)90198-9 · Cited by 534 · see citing works
PROTEIN COMPOSITION OF MYELIN OF THE PERIPHERAL NERVOUS SYSTEM
Greenfield, S., Brostoff, S. W., EYLAR, E. H., & Morell, P. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb00089.x · Cited by 447 · see citing works
Roach, A., Boylan, K., Horvath, S. J., Prusiner, S. B., & Hood, L. (1983) · Cell · doi:10.1016/0092-8674(83)90536-6 · Cited by 379 · see citing works
Self-citationAbsence of the major dense line in myelin of the mutant mouse ‘shiverer’
Privat, A., Jacque, C., Bourre, J. M., Dupouey, P., & Baumann, N. (1979) · Neuroscience Letters · doi:10.1016/0304-3940(79)91489-7 · Cited by 308 · see citing works
Neurological Mutations Affecting Myelination
Lantos, P. L. (1981) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.44.6.561 · Cited by 244 · see citing works
TAKAHASHI, N., Roach, A., Teplow, D. B., Prusiner, S. B., & Hood, L. (1985) · Cell · doi:10.1016/s0092-8674(85)80109-4 · Cited by 229 · see citing works
Self-citationCentral myelin in the mouse mutant shiverer
D, J. R. M. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940310 · Cited by 223 · see citing works
Compact myelin exists in the absence of basic protein in the shiverer mutant mouse
Kirschner, D. A., & Ganser, A. L. (1980) · Nature · doi:10.1038/283207a0 · Cited by 223 · see citing works
Omlin, F. X. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.242 · Cited by 217 · see citing works
Dupouey, P., Jacque, C., Bourre, J. M., Cesselin, F., Privat, A., & Baumann, N. (1979) · Neuroscience Letters · doi:10.1016/0304-3940(79)91490-3 · Cited by 210 · see citing works
Shiverer: an autosomal recessive mutant mouse with myelin deficiency
Chernoff, G. F. (1981) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a109442 · Cited by 189 · see citing works
Robertson, J. D. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.4.271 · Cited by 187 · see citing works
Day, E. D. (1981) · Springer eBooks · doi:10.1007/978-1-4684-3917-5_1 · Cited by 92 · see citing works
Kimura, M., Inoko, H., Katsuki, M., Ando, A., Sato, T., Hirose, T., Takashima, H., Inayama, S., Okano, H., Takamatsu, K., et al. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb12870.x · Cited by 89 · see citing works
Peripheral myelin in the mouse mutant Shiverer
Rosenbluth, J. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901930310 · Cited by 83 · see citing works
Cell‐Free Synthesis of Myelin Basic Proteins in Normal and Dysmyelinating Mutant Mice
Campagnoni, A. T., Campagnoni, C. W., Bourre, J. M., Jacque, C., & Baumann, N. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02744.x · Cited by 55 · see citing works
Organization and Structure in Central-Nerve Myelin
Rumsby, M. G. (1978) · Biochemical Society Transactions · doi:10.1042/bst0060448 · Cited by 54 · see citing works
Basic Proteins of Central and Peripheral Nervous System Myelin
CARNEGIE, P. R., & Dunkley, P. R. (1975) · Springer eBooks · doi:10.1007/978-1-4757-4395-1_3 · Cited by 48 · see citing works
Shiverer gene maps near the distal end of chromosome 18 in the house mouse
Sidman, R. L., Conover, C. S., & Carson, J. H. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132151 · Cited by 47 · see citing works
Billings‐Gagliardi, S., Hall, A. L., Stanhope, G. B., Altschuler, R. J., Sidman, R. L., & Wolf, M. K. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2558 · Cited by 16 · see citing works
Shine, H. D., & Sidman, R. L. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.4.1291 · Cited by 16 · see citing works
Peterson, A. C., & Marler, J. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90034-4 · Cited by 10 · see citing works
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Cited by
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Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828 · see citing works
Myelination of the Nervous System: Mechanisms and Functions
Nave, K., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 1,000 · see citing works
Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889 · see citing works
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes‐Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 735 · see citing works
Stolt, C. C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M. (2002) · Genes & Development · doi:10.1101/gad.215802 · Cited by 685 · see citing works
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 659 · see citing works
Boyle, M. E., Berglund, E., Murai, K., Weber, L., Peles, E., & Ranscht, B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00296-3 · Cited by 539 · see citing works
Assembly of CNS Myelin in the Absence of Proteolipid Protein
Klugmann, M., Schwab, M. H., Pühlhofer, A., Schneider, A., Zimmermann, F., Griffiths, I. R., & Nave, K. (1997) · Neuron · doi:10.1016/s0896-6273(01)80046-5 · Cited by 472 · see citing works
Readhead, C. W., Popko, B., Takahashi, N., Shine, H. D., Saavedra, R. A., Sidman, R. L., & Hood, L. (1987) · Cell · doi:10.1016/0092-8674(87)90248-0 · Cited by 397 · see citing works
Self-citationWindrem, M. S., Nunes, M. C., Rashbaum, W. K., Schwartz, T. H., Goodman, R. A., McKhann, G., Roy, N. S., & Goldman, S. A. (2004) · Nature Medicine · doi:10.1038/nm974 · Cited by 451 · see citing works
IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation
Levison, S. W., Jiang, F., Stoltzfus, O. K., & Ducceschi, M. H. (2000) · Glia · doi:10.1002/1098-1136(200012)32:3 · Cited by 71 · see citing works
Myelin Proteomics: Molecular Anatomy of an Insulating Sheath
Jahn, O., Tenzer, S., & Werner, H. B. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8071-2 · Cited by 331 · see citing works
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
Rasband, M. N., Peles, E., Trimmer, J. S., Levinson, S. R., Lux, S. E., & Shrager, P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07516.1999 · Cited by 325 · see citing works
Windrem, M. S., Schanz, S. J., Guo, M., Tian, G.-F., Washco, V., Stanwood, N. L., Rasband, M. N., Roy, N. S., Nedergaard, M., Havton, L. A., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.020 · Cited by 315 · see citing works
Myelin synthesis in the peripheral nervous system
Garbay, B. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00049-0 · Cited by 308 · see citing works
Tait, S., Gunn-Moore, F., Collinson, J., Huang, J., Lubetzki, C., Pedraza, L., Sherman, D., Colman, D., & Brophy, P. (2000) · Journal of Cell Biology · doi:10.1083/jcb.150.3.657 · Cited by 339 · see citing works
Warrington, A. E., Barbarese, E., & Pfeiffer, S. E. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340102 · Cited by 262 · see citing works
Srinivasan, J., Schachner, M., & Catterall, W. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15753 · Cited by 249 · see citing works
The Axon-Myelin Unit in Development and Degenerative Disease
Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246 · see citing works
Unwrapping the genes of myelin
Lemke, G. (1988) · Neuron · doi:10.1016/0896-6273(88)90103-1 · Cited by 244 · see citing works
Molecular Biology of Myelin Proteins from the Central Nervous System
Campagnoni, A. T. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb04827.x · Cited by 238 · see citing works
TAKAHASHI, N., Roach, A., Teplow, D. B., Prusiner, S. B., & Hood, L. (1985) · Cell · doi:10.1016/s0092-8674(85)80109-4 · Cited by 229 · see citing works
Self-citationCellular and molecular aspects of myelin protein gene expression
Campagnoni, A. T., & Macklin, W. B. (1988) · Molecular Neurobiology · doi:10.1007/bf02935632 · Cited by 226 · see citing works
Campagnoni, A. T., Pribyl, T. M., Campagnoni, C. W., Kampf, K., Amur-Umarjee, S. G., Landry, C. F., Handley, V., Newman, S. L., Garbay, B., & KITAMURA, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53485-2 · Cited by 224 · see citing works
Identity, distribution, and development of polydendrocytes: NG2-expressing glial cells
Nishiyama, A., Watanabe, M., Yang, Z., & Bu, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025783412651 · Cited by 211 · see citing works
Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder.
Hudson, L. D., Robinson, C. P., Berndt, J. A., Chan, J. A.-W., & Gencic, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8128 · Cited by 205 · see citing works
Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton
Brady, S. T., Witt, A. S., Kirkpatrick, L., de Waegh, S. M., Readhead, C. W., Tu, P., & Lee, V. M. ‐. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07278.1999 · Cited by 197 · see citing works
Popko, B. (1987) · Cell · doi:10.1016/0092-8674(87)90249-2 · Cited by 192 · see citing works
Chang, E. H., Argyelan, M., Aggarwal, M., Chandon, T.-S. S., Karlsgodt, K. H., Mori, S., & Malhotra, A. K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.068 · Cited by 186 · see citing works
Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire
Targoni, O. S., & Lehmann, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2055 · Cited by 185 · see citing works
Izrael, M., Zhang, P., Kaufman, R., Shinder, V., Ella, R., Amit, M., Itskovitz‐Eldor, J., Chebath, J., & Revel, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.008 · Cited by 179 · see citing works
Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein
Harrington, C., Paez, A., Hunkapiller, T., Mannikko, V., Brabb, T., Ahearn, M., Beeson, C. C., & Goverman, J. M. (1998) · Immunity · doi:10.1016/s1074-7613(00)80562-2 · Cited by 179 · see citing works
Tyszka, J., Readhead, C., Bearer, E., Pautler, R., & Jacobs, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.037 · Cited by 187 · see citing works
Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.
Hudson, L. D., Berndt, J. A., Robinson, C. P., Kozak, C. A., & Lazzarini, R. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1454 · Cited by 174 · see citing works
Nave, K., Bloom, F. E., & Milner, R. J. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb02449.x · Cited by 167 · see citing works
Gencic, S., Abuelo, D. N., Ambler, M., & Hudson, L. D. (1989) · Europe PMC (PubMed Central) · Cited by 166 · see citing works
Bercury, K. K., Dai, J., Sachs, H. H., Ahrendsen, J. T., Wood, T. L., & Macklin, W. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4314-13.2014 · Cited by 160 · see citing works
Chromosome maps of man and mouse, III
Searle, A. G., Peters, J., Lyon, M. F., Evans, E. P., Edwards, J. H., & Buckle, V. J. (1987) · Genomics · doi:10.1016/0888-7543(87)90099-1 · Cited by 160 · see citing works
Widespread Expression of Netrin-1 by Neurons and Oligodendrocytes in the Adult Mammalian Spinal Cord
Manitt, C., Colicos, M. A., Thompson, K. M., Rousselle, E., Peterson, A. C., & Kennedy, T. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03911.2001 · Cited by 159 · see citing works
Myelin sheath structure and regeneration in peripheral nerve injury repair
Liu, B., Wang, X., Tan, J.-R., Zhu, R.-P., Li, T., Wang, D., Kan, S., Xiong, D.-K., Li, H., Zhang, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910292116 · Cited by 158 · see citing works
Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene
Tienari, P. J., Sajantila, A., Peltonen, L., Tienari, P. J., Wikstrom, J., & Palo, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)93007-a · Cited by 158 · see citing works
Subunit Composition of Kv1 Channels in Human CNS
Coleman, S. K., Newcombe, J., Pryke, J., & Dolly, J. O. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730849.x · Cited by 156 · see citing works
The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shi mld )
Readhead, C. W., & Hood, L. (1990) · Behavior Genetics · doi:10.1007/bf01067791 · Cited by 153 · see citing works
Self-citationThe structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice
Dautigny, A., Mattéi, M., Morello, D., Alliel, P. M., Pham-Dinh, D., Amar, L., Arnaud, D., Simon‐Chazottes, D., Mattéi, J. F., Guénet, J., et al. (1986) · Nature · doi:10.1038/321867a0 · Cited by 153 · see citing works
mRNA In The Mammalian Central Nervous System
Sutcliffe, J. G. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001105 · Cited by 152 · see citing works
ffrench‐Constant, C., Miller, R. H., Burne, J. F., & RAFF, M. C. (1988) · Journal of Neurocytology · doi:10.1007/bf01735374 · Cited by 151 · see citing works
Verity, A. N., & Campagnoni, A. T. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210216 · Cited by 151 · see citing works
Yasuda, A., Tsuji, O., Shibata, S., Nori, S., Takano, M., Kobayashi, Y., Takahashi, Y., Fujiyoshi, K., Hara, C. M., Miyawaki, A., et al. (2011) · Stem Cells · doi:10.1002/stem.767 · Cited by 148 · see citing works
Gow, A., Friedrich, V. L., & Lazzarini, R. A. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.3.605 · Cited by 147 · see citing works
Cholesterol: A Novel Regulatory Role in Myelin Formation
Saher, G., Quintes, S., & Nave, K.-A. (2011) · The Neuroscientist · doi:10.1177/1073858410373835 · Cited by 144 · see citing works
Duncan, I. D., Hammang, J. P., & Trapp, B. D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6287 · Cited by 144 · see citing works
Molineaux, S. M., Engh, H., de Ferra, F., Hudson, L., & Lazzarini, R. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7542 · Cited by 141 · see citing works
Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain
Westenbroek, R. E., Noebels, J. L., & Catterall, W. A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-06-02259.1992 · Cited by 139 · see citing works
The Pathobiology of Myelin Mutants Reveal Novel Biological Functions of the MBP and PLP Genes
Campagnoni, A. T., & Skoff, R. P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00383.x · Cited by 138 · see citing works
Myelin basic protein‐dependent plasma membrane reorganization in the formation of myelin
Fitzner, D., Schneider, A., Kippert, A., Möbius, W., Willig, K. I., Hell, S. W., Bunt, G., Gaus, K., & Simons, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601376 · Cited by 135 · see citing works
Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination
Uchida, N., Chen, K., Dohse, M., Hansen, K., Dean, J. M., Buser, J. R., Riddle, A., Beardsley, D. J., Wan, Y., Gong, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004371 · Cited by 135 · see citing works
Pedraza, L., Fidler, L., Staugaitis, S. M., & Colman, D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80299-8 · Cited by 135 · see citing works
Comparative map for mice and humans
Nadeau, J. H., Davisson, M. T., Doolittle, D. P., Grant, P., Hillyard, A. L., Kosowsky, M., & Roderick, T. H. (1992) · Mammalian Genome · doi:10.1007/bf00778825 · Cited by 132 · see citing works
Molecular genetic markers spanning mouse chromosome 10
Kozak, C. A., Peyser, M., Krall, M., Mariano, T. M., Kumar, C. S., Pestka, S., & Mock, B. A. (1990) · Genomics · doi:10.1016/0888-7543(90)90039-w · Cited by 119 · see citing works
Nawaz, S., Kippert, A., Saab, A. S., Werner, H. B., Lang, T., Nave, K.-A., & Simons, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3955-08.2009 · Cited by 116 · see citing works
Verity, A. N., Bredesen, D. E., Vonderscher, C., Handley, V., & Campagnoni, A. T. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03188.x · Cited by 115 · see citing works
K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve
Rasband, M. N., Trimmer, J. S., Peles, E., Levinson, S. R., & Shrager, P. G. (1999) · Journal of Neurocytology · doi:10.1023/a:1007057512576 · Cited by 110 · see citing works
Age-Dependent T Cell Tolerance and Autoimmunity to Myelin Basic Protein
Huseby, E. S., Sather, B. D., Huseby, P. G., & Goverman, J. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00127-3 · Cited by 109 · see citing works
Immune tolerance in multiple sclerosis
Goverman, J. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01016.x · Cited by 109 · see citing works
Sorg, B. A., Smith, M. M., & Campagnoni, A. T. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb10005.x · Cited by 108 · see citing works
Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse
Andrews, H., White, K., Thomson, C. E., Edgar, J. M., Bates, D., Griffiths, I. R., Turnbull, D. M., & Nichols, P. P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20842 · Cited by 104 · see citing works
Three-dimensional Structure of Myelin Basic Protein
Ridsdale, R. A., Beniac, D. R., Tompkins, T. A., Moscarello, M. A., & Harauz, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4269 · Cited by 103 · see citing works
Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice
Gencic, S., & Hudson, L. D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00117.1990 · Cited by 102 · see citing works
Myelination in the human hippocampal formation from midgestation to adulthood
Ábrahám, H., Vincze, A., Jewgenow, I., Veszprémi, B., Kravják, A., Gömöri, É., & Seress, L. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.03.004 · Cited by 94 · see citing works
The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay
Jahn, O., Siems, S. B., Kusch, K., Hesse, D., Jung, R. B., Liepold, T., Uecker, M., Sun, T., & Werner, H. B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00239 · Cited by 99 · see citing works
Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain
Roussel, G., Nešković, N., Trifilieff, É., Artault, J.-C., & Nussbaum, J. L. (1987) · Journal of Neurocytology · doi:10.1007/bf01795303 · Cited by 99 · see citing works
Neurological mouse mutants and the genes of myelin
Nave, K. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380602 · Cited by 98 · see citing works
Isolation and characterization of a novel oligodendrocyte-specific protein
Bronstein, J. M., Popper, P., Micevych, P. E., & Farber, D. B. (1996) · Neurology · doi:10.1212/wnl.47.3.772 · Cited by 97 · see citing works
Three-dimensional Structure of Myelin Basic Protein
Beniac, D. R., Luckevich, M. D., Czarnota, G. J., Tompkins, T. A., Ridsdale, R. A., Ottensmeyer, F. P., Moscarello, M. A., & Harauz, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4261 · Cited by 96 · see citing works
Macklin, W. B., Gardinier, M. V., King, K. D., & Kampf, K. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80331-9 · Cited by 93 · see citing works
Myelination in the jimpy mouse in the absence of proteolipid protein
Duncan, I. D., Hammang, J. P., Goda, S., & Quarles, R. H. (1989) · Glia · doi:10.1002/glia.440020303 · Cited by 92 · see citing works
Identification and applications of repetitive probes for gene mapping in the mouse.
Siracusa, L. D., Jenkins, N. A., & Copeland, N. G. (1991) · Genetics · doi:10.1093/genetics/127.1.169 · Cited by 91 · see citing works
Shine, H. D., Readhead, C., Popko, B., Hood, L., & Sidman, R. L. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09316.x · Cited by 111 · see citing works
Self-citationFyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
Matrone, C., Petrillo, F., Nasso, R., & Ferretti, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124444 · Cited by 86 · see citing works
Narrowing critical regions and determining penetrance for selected 18q‐ phenotypes
Cody, J. D., Heard, P. L., Crandall, A. C., Carter, E. M., Li, J., Hardies, L. J., Lancaster, J. L., Perry, B. P., Stratton, R. F., Sebold, C. D., et al. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32899 · Cited by 90 · see citing works
Organization and expression of the human myelin basic protein gene
Kamholz, J. A., Toffenetti, J., & Lazzarini, R. A. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210110 · Cited by 90 · see citing works
Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler
Wang, H., Allen, M. L., Grigg, J. J., Noebels, J. L., & Tempel, B. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90012-8 · Cited by 88 · see citing works
Electron microscopy of myelin: Structure preservation by high-pressure freezing
Möbius, W., Nave, K., & Werner, H. B. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.027 · Cited by 86 · see citing works
Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion
Noebels, J. L., Marcom, P. K., & Tehrani, M. H. J. (1991) · Nature · doi:10.1038/352431a0 · Cited by 86 · see citing works
Vincze, A., Mázló, M., Seress, L., Komoly, S., & Ábrahám, H. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.05.003 · Cited by 85 · see citing works
Möbius, W., Patzig, J., Nave, K., & Werner, H. B. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x0900009x · Cited by 84 · see citing works
Characterization of Myelin Proteolipid mRNAs in Normal and Jimpy Mice
Gardinier, M. V., Macklin, W. B., Diniak, A. J., & Deininger, P. L. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3755 · Cited by 84 · see citing works
Expression of myelin proteolipid and basic protein mRNAS in cultured cells
Macklin, W. B., Weill, C. L., & Deininger, P. L. (1986) · Journal of Neuroscience Research · doi:10.1002/jnr.490160118 · Cited by 83 · see citing works
The transcriptome of mouse central nervous system myelin
Thakurela, S., Garding, A., Jung, R. B., Müller, C., Goebbels, S., White, R., Werner, H. B., & Tiwari, V. K. (2016) · Scientific Reports · doi:10.1038/srep25828 · Cited by 81 · see citing works
Chronic multifocal osteomyelitis, a new recessive mutation on Chromosome 18 of the mouse
Byrd, L. G., Grossmann, M. E., Potter, M., & Shen-Ong, G. L. C. (1991) · Genomics · doi:10.1016/0888-7543(91)90002-v · Cited by 83 · see citing works
Ding, Y., & Brunden, K. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34125-x · Cited by 83 · see citing works
Impaired myelination of the human hippocampal formation in Down syndrome
Ábrahám, H., Vincze, A., Veszprémi, B., Kravják, A., Gömöri, É., Kovács, G. G., & Seress, L. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.11.005 · Cited by 85 · see citing works
Towards the reconstruction of central nervous system white matter using neural precursor cells
Mitome, M. (2001) · Brain · doi:10.1093/brain/124.11.2147 · Cited by 80 · see citing works
Uschkureit, T., Spörkel, O., Stracke, J., Büssow, H., & Stoffel, W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05225.2000 · Cited by 79 · see citing works
Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism
Zhang, Y., Lu, Z., Ku, L., Chen, Y., Wang, H., & Feng, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg171 · Cited by 76 · see citing works
CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
Perchellet, A., Stromnes, I. M., Pang, J. M., & Goverman, J. M. (2004) · Nature Immunology · doi:10.1038/ni1073 · Cited by 75 · see citing works
Hudson, L. D., Friedrich, V. L., Behar, T. N., Dubois-Dalcq, M. E., & Lazzarini, R. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.717 · Cited by 75 · see citing works
Cortical network dysfunction caused by a subtle defect of myelination
Poggi, G., Boretius, S., Möbius, W., Moschny, N., Baudewig, J., Ruhwedel, T., Hassouna, I. A., Wieser, G. L., Werner, H. B., Goebbels, S., et al. (2016) · Glia · doi:10.1002/glia.23039 · Cited by 74 · see citing works
Tailoring the genome: the power of genetic approaches
Nagy, A., Perrimon, N., Sandmeyer, S. B., & Plasterk, R. H. A. (2003) · Nature Genetics · doi:10.1038/ng1115 · Cited by 75 · see citing works
Holz, A., Schaeren‐Wiemers, N., Schaefer, C. B., Pott, U., Colello, R. J., & Schwab, M. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00467.1996 · Cited by 74 · see citing works
- Authors
- ROACH, A., TAKAHASHI, N., PRAVTCHEVA, D., RUDDLE, F., & HOOD, L.
- Affiliations
- California Institute of Technology (US)
- Yale University (US)
- ORCID
- HOOD, L
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1985-08
- Volume
- 42
- Issue
- 1
- Pages
- 149-155
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151814085
- Cited by
- 336
- References
- 32
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 13 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- myelin basic protein, chromosome 18, gene mapping, partial gene deletion, CNS myelination, alternative splicing, transcription initiation, polyadenylation, exon deletion
- MeSH terms
- Animals, Base Sequence, Brain, Chromosome Deletion, Chromosome Mapping, Myelin Basic Protein, Genes, Genetic Linkage, Mice, Neurologic Mutants, Mutation, Poly A, RNA Splicing, RNA, Messenger, Transcription, Genetic, Mice
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