The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney.
Open accessAbstract
The hypothesis was tested if the mineralocorticoid hormone aldosterone stimulates Na+/H+ exchange in "giant cells" fused from individual target cells of the distal nephron of the frog kidney. By means of microelectrodes, steady-state intracellular pH (pHi) and pHi recovery from an acid load were recorded continuously while the fused cells were exposed to aldosterone. Twenty minutes after addition of the hormone, pHi started to rise and reached a new steady state after about 60 min (delta pHi = 0.28 +/- 0.01). After hormone treatment, pHi recovered significantly faster in response to an intracellular acid load. The diuretic drug amiloride blocked pHi recovery. Experiments in intact tubules showed that aldosterone induces H+ and K+ secretion. Thus, intracellular alkalosis, mediated by Na+/H+ exchange, could serve as a signal that activates pH-sensitive K+ channels of the luminal cell membrane.
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Field, M. J., Stanton, B. A., & Giebisch, G. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111598 · Cited by 140
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Nongenomic steroid action: controversies, questions, and answers
LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00003.2003 · Cited by 561
Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor.
Lombès, M., Oblin, M. E., Gasc, J. M., Baulieu, E. E., Farman, N., & Bonvalet, J. P. (1992) · Circulation Research · doi:10.1161/01.res.71.3.503 · Cited by 309
Aldosterone Blunts Tubuloglomerular Feedback by Activating Macula Densa Mineralocorticoid Receptors
Fu, Y., Hall, J. E., Lu, D., Lin, L., Manning, R. D., Cheng, L., Gomez-Sanchez, C. E., Juncos, L. A., & Liu, R. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.173195 · Cited by 65
Metadata
- Authors
- Oberleithner, H., Weigt, M., Westphale, H. J., & Wang, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-03
- Volume
- 84
- Issue
- 5
- Pages
- 1464-1468
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024640638
- Cited by
- 186
- References
- 1
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Oberleithner, H., Weigt, M., Westphale, H. J., & Wang, W. (1987). Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.5.1464
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
