The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
Open accessAbstract
The nonobese diabetic mouse is recognized as an important animal model for human insulin-dependent diabetes mellitus. One of the components of susceptibility to this disease has been mapped to the major histocompatibility complex. In this study, full-length cDNA clones encoding the I-A alpha and beta chains from the nonobese diabetic mouse have been isolated and sequenced. They are identical to the sequences previously determined from the H-2d haplotype except for the sequence encoding the first external domain, the leader peptide, and the 5' untranslated region of the I-A beta chain molecule. Most strikingly, there are five consecutive nucleotide substitutions which lead to two radical amino acid changes in a region that is conserved between human and mouse. We suggest that the unique structure of the first external I-A beta chain domain is a major determinant in the disease susceptibility that maps to the major histocompatibility complex of the nonobese diabetic mouse.
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Metadata
- Authors
- Acha-Orbea, H., & McDevitt, H. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-04
- Volume
- 84
- Issue
- 8
- Pages
- 2435-2439
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066626286
- Cited by
- 398
- References
- 20
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Acha-Orbea, H., & McDevitt, H. O. (1987). The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.8.2435
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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