The DOI matches its Crossref record.
The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex
Abstract
Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E α , and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.
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Citations
Cited by
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,931
Self-citationEisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659
Following a diabetogenic T cell from genesis through pathogenesis
Katz, J. D., Wang, B., Haskins, K., Benoist, C., & Mathis, D. (1993) · Cell · doi:10.1016/0092-8674(93)90730-e · Cited by 696
T Helper Cell Subsets in Insulin-Dependent Diabetes
Katz, J. D., Benoist, C., & Mathis, D. (1995) · Science · doi:10.1126/science.7761837 · Cited by 593
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
Acha-Orbea, H., & McDevitt, H. O. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2435 · Cited by 398
Metadata
- Authors
- Hattori, M., Buse, J. B., Jackson, R. A., Glimcher, L., Dorf, M. E., Minami, M., Makino, S., Moriwaki, K., Kuzuya, H., Imura, H., Strauss, W. M., Seidman, J. G., & Eisenbarth, G. S.
- Venue
- Science
- Published
- 1986-02-14
- Volume
- 231
- Issue
- 4739
- Pages
- 733-735
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973485458
- Cited by
- 418
- References
- 0
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hattori, M., Buse, J. B., Jackson, R. A., Glimcher, L., Dorf, M. E., Minami, M., Makino, S., Moriwaki, K., Kuzuya, H., Imura, H., Strauss, W. M., Seidman, J. G., & Eisenbarth, G. S. (1986). The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex. Science. https://doi.org/10.1126/science.3003909
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
