The DOI matches its Crossref record.
Selective destruction of protein function by chromophore-assisted laser inactivation.
Open accessAbstract
Chromophore-assisted laser inactivation of protein function has been achieved. After a protein binds a specific ligand or antibody conjugated with malachite green (C.I. 42,000), it is selectively inactivated by laser irradiation at a wavelength of light absorbed by the dye but not significantly absorbed by cellular components. Ligand-bound proteins in solution and on the surfaces of cells can be denatured without other proteins in the same samples being affected. Chromophore-assisted laser inactivation can be used to study cell surface phenomena by inactivating the functions of single proteins on living cells, a molecular extension of cellular laser ablation. It has an advantage over genetics and the use of specific inhibitors in that the protein function of a single cell within the organism can be inactivated by focusing the laser beam.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Fluorescent Proteins and Their Applications in Imaging Living Cells and Tissues
Chudakov, D. M., Matz, M. V., Lukyanov, S., & Lukyanov, K. A. (2010) · Physiological Reviews · doi:10.1152/physrev.00038.2009 · Cited by 1,375
Symposium‐in‐Print: Singlet Oxygen Invited Review
Redmond, R. W., & Kochevar, I. E. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-04-14-ir-874 · Cited by 421
In vivo protein labeling with trimethoprim conjugates: a flexible chemical tag
Miller, L. W., Cai, Y., Sheetz, M. P., & Cornish, V. W. (2005) · Nature Methods · doi:10.1038/nmeth749 · Cited by 323
Zheng, F., Yu, C., Zhou, X., & Zou, P. (2023) · Nature Communications · doi:10.1038/s41467-023-38565-8 · Cited by 76
Kerekes, B. P., Toth, K., Kaszás, A., Chiovini, B., Szadai, Z., Szalay, G., Palfi, D., Spitzer, K., Rózsa, B., Ulbert, I., et al. (2014) · Neurophotonics · doi:10.1117/1.nph.1.1.011013 · Cited by 16
Metadata
- Authors
- Jay, D. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 15
- Pages
- 5454-5458
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987683665
- Cited by
- 253
- References
- 0
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selective destruction of protein function by chromophore-assisted laser inactivation. https://app.cochat.ai/papers/10.1073/pnas.85.15.5454
- The paper
- Jay, D. G. (1988). Selective destruction of protein function by chromophore-assisted laser inactivation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.15.5454
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
