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Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.
Open accessAbstract
Twenty different target sites within human immunodeficiency virus (HIV) RNA were selected for studies of inhibition of HIV replication by antisense oligonucleotides. Target sites were selected based on their potential capacity to block recognition functions during viral replication. Antisense oligomers complementary to sites within or near the sequence repeated at the ends of retrovirus RNA (R region) and to certain splice sites were most effective. The effect of antisense oligomer length on inhibiting virus replication was also investigated, and preliminary toxicity studies in mice show that these compounds are toxic only at high levels. The results indicate potential usefulness for these oligomers in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex either alone or in combination with other drugs.
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Cited by
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
Agrawal, S., Temsamani, J., & Tang, J. Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7595 · Cited by 561
Self-citationTetranucleotide GGGA Motif in Primary RNA Transcripts
Tu, G.-C., Cao, Q.-N., Zhou, F., & Israel, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25125 · Cited by 93
Bhagat, L., Putta, M. R., Wang, D., Yu, D., Lan, T., Jiang, W., Sun, Z., Wang, H., Tang, J. X., La Monica, N., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200113t · Cited by 20
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Metadata
- Authors
- Goodchild, J., Agrawal, S., Civeira, M. P., Sarin, P. S., Sun, D., & Zamecnik, P. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 15
- Pages
- 5507-5511
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2083862437
- Cited by
- 229
- References
- 0
- FWCI
- 21.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Goodchild, J., Agrawal, S., Civeira, M. P., Sarin, P. S., Sun, D., & Zamecnik, P. C. (1988). Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.15.5507
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