The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
Open accessAbstract
We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleotide linkage) was found in most of the tissues for up to 48 hr. About 30% of the dose was excreted in urine within 24 hr, irrespective of the mode of administration; the excreted [S]oligonucleotide was found to be extensively degraded. In plasma, stomach, heart, and intestine, the [S]oligonucleotide was degraded by only 15%, whereas in the kidney and liver degradation was about 50% in 48 hr. The surprising observation was made that chain length extension of administered [S]oligonucleotide occurred in kidney, liver, and intestine. These results provide an initial definition of parameters for the pharmaceutical development of antisense oligonucleotides.
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Matsukura, M., Shinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J. S., & Broder, S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7706 · Cited by 533
Zamecnik, P. C., Goodchild, J., Taguchi, Y., & Sarin, P. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4143 · Cited by 400
Agrawal, S., Goodchild, J., Civeira, M. P., Thornton, A. H., Sarin, P. S., & Zamecnik, P. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7079 · Cited by 291
Self-citationMatsukura, M., Zon, G., Shinozuka, K., Robert-Guroff, M., Shimada, T., Stein, C. A., Mitsuya, H., Wong-Staal, F., Cohen, J. S., & Broder, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4244 · Cited by 262
α-Oligodeoxynucleotide stability in serum, subcellular extracts and culture media
Bacon, T. A., Morvan, F., Rayner, B., Imbach, J.-L., & Wickstrom, E. (1988) · Journal of Biochemical and Biophysical Methods · doi:10.1016/0165-022x(88)90065-6 · Cited by 255
Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.
Goodchild, J., Agrawal, S., Civeira, M. P., Sarin, P. S., Sun, D., & Zamecnik, P. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5507 · Cited by 229
Self-citationAgrawal, S., Ikeuchi, T., Sun, D., Sarin, P. S., Konopka, A., Maizel, J., & Zamecnik, P. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7790 · Cited by 210
Self-citationInhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates.
Sarin, P. S., Agrawal, S., Civeira, M. P., Goodchild, J., Ikeuchi, T., & Zamecnik, P. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7448 · Cited by 132
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Metadata
- Authors
- Agrawal, S., Temsamani, J., & Tang, J. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-09
- Volume
- 88
- Issue
- 17
- Pages
- 7595-7599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2067401769
- Cited by
- 561
- References
- 8
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Agrawal, S., Temsamani, J., & Tang, J. Y. (1991). Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.17.7595
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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