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Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.
Open accessAbstract
Modified oligodeoxynucleotides complementary to RNA of human immunodeficiency virus 1 (HIV-1) were tested for their ability to inhibit virally induced syncytium formation and expression of viral p24 protein. The modifications of oligomers include replacement of backbone phosphodiester groups with phosphorothioates and various phosphoramidates. All oligomers were found to be active. Oligomers with complete replacement of phosphodiesters with phosphoramidate or phosphorothioate groups were more active at the micromolar range than were unmodified oligomers of the same sequence. In addition, modified and unmodified homooligonucleotides also showed inhibition of HIV-1 replication. It is suggested that different classes of oligonucleotides may inhibit HIV replication by different mechanisms.
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Cited by
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Dowdy, S. F. (2017) · Nature Biotechnology · doi:10.1038/nbt.3802 · Cited by 1,139
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Eckstein, F. (2014) · Nucleic Acid Therapeutics · doi:10.1089/nat.2014.0506 · Cited by 684
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
Agrawal, S., Temsamani, J., & Tang, J. Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7595 · Cited by 561
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Metadata
- Authors
- Agrawal, S., Goodchild, J., Civeira, M. P., Thornton, A. H., Sarin, P. S., & Zamecnik, P. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-10
- Volume
- 85
- Issue
- 19
- Pages
- 7079-7083
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079242913
- Cited by
- 291
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Agrawal, S., Goodchild, J., Civeira, M. P., Thornton, A. H., Sarin, P. S., & Zamecnik, P. C. (1988). Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.19.7079
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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