The DOI matches its Crossref record.
Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.
Open accessAbstract
Serum and growth factor regulation of c-FOS protooncogene transcription is mediated by the serum response element. A factor, serum response factor, binding to this element has already been identified. We demonstrate that serum response factor is phosphorylated in vivo on serine residues and that phosphatase treatment of this factor in vitro abolishes its DNA-binding activity. These results show phosphorylation of serum response factor to be required for its DNA-binding activity. The importance of serum response factor phosphorylation for the regulation of c-FOS expression is discussed.
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Cited by
Carpenter, G., & Cohen, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38983-5 · Cited by 1,622
Ma, H., Yanofsky, M. F., & Meyerowitz, E. M. (1991) · Genes & Development · doi:10.1101/gad.5.3.484 · Cited by 630
Janknecht, R., de Martynoff, G., Lou, J., Hipskind, R. A., Nordheim, A., & Stunnenberg, H. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.8972 · Cited by 451
Mellinghoff, I. K., Vivanco, I., Kwon, A., Tran, C., Wongvipat, J., & Sawyers, C. L. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.031 · Cited by 344
Rivera, V. M., Miranti, C. K., Misra, R. P., Ginty, D. D., Chen, R. H., Blenis, J., & Greenberg, M. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6260 · Cited by 258
Metadata
- Authors
- Prywes, R., Dutta, A., Cromlish, J. A., & Roeder, R. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-10
- Volume
- 85
- Issue
- 19
- Pages
- 7206-7210
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045457726
- Cited by
- 173
- References
- 0
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer. https://app.cochat.ai/papers/10.1073/pnas.85.19.7206
- The paper
- Prywes, R., Dutta, A., Cromlish, J. A., & Roeder, R. G. (1988). Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.19.7206
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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