The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.
Open accessAbstract
We have recently identified by cDNA cloning a set of genes that are rapidly activated in mouse 3T3 cells by serum or purified growth factors. Here we report that the cDNA (clone 268) derived from one of these immediate early genes (zif/268) encodes a protein with three tandem "zinc finger" sequences typical of a class of eukaryotic transcription factors. The mRNA of zif/268 is present in many organs and tissues of the mouse and is especially abundant in the brain and thymus tissue. The 5' genomic flanking sequence of zif/268 has sequences related to binding sites for known regulatory proteins, including four sequences that resemble the core of the serum response elements (SREs) upstream of the c-fos and actin genes. The SRE-like sequences could be responsible for the coordinate activation of zif/268 and fos after serum stimulation of 3T3 cells.
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Cites
Pelletier, J., & Sonenberg, N. (1985) · Cell · doi:10.1016/0092-8674(85)90200-4 · Cited by 610
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Lau, L. F., & Nathans, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04057.x · Cited by 567
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Cited by
Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548
The biology of the mammalian Krüppel-like family of transcription factors
Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458
Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)90660-i · Cited by 367
Clayton, D. F. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3967 · Cited by 322
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
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Metadata
- Authors
- Christy, B. A., Lau, L. F., & Nathans, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 21
- Pages
- 7857-7861
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052537645
- Cited by
- 706
- References
- 2
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- green
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