The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.
Open accessAbstract
To understand the mechanisms of oncogenesis by human T-cell leukemia virus type I, we have investigated the ability of the tax1, protein to modulate transcription of protooncogenes. By using a transient cotransfection assay, we report that the protooncogene fos promoter is transactivated by tax1 in a variety of cell types. Two regions containing upstream sequences between positions -362/-324 and -323/-276 of the c-fos promoter responded to this activation and also conferred tax1 responsiveness to the heterologous herpesvirus thymidine kinase promoter. These two sequences include elements mediating the induction by v-sis-conditioned medium and serum, phorbol ester, or epidermal growth factor, respectively. Furthermore, expression of the endogenous c-fos gene was activated by tax1 in human T-cell leukemia virus type I-infected cell lines. In contrast, no trans-activation of the c-myc or c-Ha-ras promoter was observed.
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Cites
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Self-citationHTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
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Cited by
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Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P., & Bangham, C. R. M. (2009) · Blood · doi:10.1182/blood-2008-03-136770 · Cited by 118
Metadata
- Authors
- Fujii, M., Sassone-Corsi, P., & Verma, I. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 22
- Pages
- 8526-8530
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032496145
- Cited by
- 351
- References
- 40
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Fujii, M., Sassone-Corsi, P., & Verma, I. M. (1988). c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.22.8526
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