Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.
Open accessAbstract
Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm of 1--5% of the cells of a T-cell line, MT-1, from a patient with adult T-cell leukemia (ATL), which is endemic in southwestern Japan. The antigen was not detected in other human lymphoid cell lines, including six T-cell lines, seven B-cell lines, and four non-T non-B cell lines. The antigen did not show cross antigenicity with that of herpesviruses, including Epstein--Barr virus, herpes simplex virus, cytomegalovirus, varicella-zoster virus, herpesvirus saimiri, and Marek disease virus. The proportion of antigen-bearing cells was increased by a factor of approximately 5 on culture in the presence of 5-iodo-2'-deoxyuridine. Antibodies against the antigen in MT-1 cells were found in all 44 patients with ATL examined and in 32 of 40 patients with malignant T-cell lymphomas (most of them had diseases similar to ATL except that leukemic cells were not found in the peripheral blood). The antibodies were also detected in 26% of the healthy adults examined from ATL-endemic areas but in only a few of those examined from ATL-non-endemic areas. On electron microscopy, extracellular type C virus particles were detected in pelleted MT-1 cells cultured in the presence of 5-iodo-2'-deoxyuridine.
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HTLV-1 is primarily associated with ATL and HAM.
“HTLV-1 is primarily associated with the aggressive haematological malignancy ATL [1,2] and a chronic inflammatory disease called HTLV-1-associated myelopathies (HAM).”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [2]
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- Authors
- Hinuma, Y., Nagata, K., Hanaoka, M., Nakai, M., Matsumoto, T., Kinoshita, K. I., Shirakawa, S., & Miyoshi, I.
- ORCID
- Matsumoto, T
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1981-10
- Volume
- 78
- Issue
- 10
- Pages
- 6476-6480
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC349062
- OpenAlex
- W2048022927
- Cited by
- 2,252
- References
- 1
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 18 · 2023: 19 · 2022: 28 · 2021: 13 · 2020: 24 · 2019: 28 · 2018: 26 · 2017: 36 · 2016: 30 · 2015: 22 · 2014: 30 · 2013: 43 · 2012: 47
- FWCI
- 38.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Keywords
- adult T-cell leukemia/lymphoma, cell surface antigens, 5-iodo-2'-deoxyuridine, C-type virus, virus particles, Epstein-Barr virus, Herpesvirus saimiri, cytoplasmic antigens
- MeSH terms
- Adult, Antibodies, Neoplasm, Antigen-Antibody Complex, Antigens, Neoplasm, Cell Line, Cross Reactions, Fluorescent Antibody Technique, Humans, Japan, Leukemia, T-Lymphocytes
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