The DOI matches its Crossref record.
Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.
Open accessAbstract
We report the stoichiometric phosphorylation of an inositol 1,4,5-trisphosphate receptor-binding protein from rat brain by the cAMP-dependent protein kinase but not by protein kinase C or Ca2+/calmodulin-dependent protein kinase. This phosphorylation event does not markedly alter [3H]inositol 1,4,5-trisphosphate-binding characteristics. However, inositol 1,4,5-trisphosphate is only 10% as potent in releasing 45Ca2+ from phosphorylated, as compared with native, cerebellar microsomes. Phosphorylation of the inositol 1,4,5-trisphosphate-binding protein by the cAMP-dependent protein kinase may provide a biochemical substrate for second-messenger cross talk.
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Citations
Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400
Furuichi, T., Yoshikawa, S., Miyawaki, A., Wada, K., Maeda, N., & Mikoshiba, K. (1989) · Nature · doi:10.1038/342032a0 · Cited by 1,049
Takata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., Yamamura, H., & Kurosaki, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06387.x · Cited by 650
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
Mignery, G. A., Südhof, T. C., Takei, K., & De Camilli, P. (1989) · Nature · doi:10.1038/342192a0 · Cited by 532
Metadata
- Authors
- Supattapone, S., Danoff, S. K., Theibert, A., Joseph, S. K., Steiner, J., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 22
- Pages
- 8747-8750
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021094409
- Cited by
- 352
- References
- 0
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Supattapone, S., Danoff, S. K., Theibert, A., Joseph, S. K., Steiner, J., & Snyder, S. H. (1988). Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.22.8747
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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