Inositol Trisphosphate Receptor Ca2+Release Channels
Open accessAbstract
The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R.
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IP3 receptors are located in the ER membrane.
“Because IP 3 receptors (1) and the erlin1/2 complex (15) are located in the ER membrane”
From RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation (2011) · cites this paper as [1]
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- Authors
- Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2007-04
- Volume
- 87
- Issue
- 2
- Pages
- 593-658
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC2901638
- OpenAlex
- W2096199252
- Cited by
- 1,188
- References
- 7
- Citations by year
- 2026: 29 · 2025: 45 · 2024: 52 · 2023: 52 · 2022: 56 · 2021: 58 · 2020: 58 · 2019: 55 · 2018: 69 · 2017: 57 · 2016: 68 · 2015: 53 · 2014: 97 · 2013: 74 · 2012: 91
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH059937)
- National Institute of General Medical Sciences (R01GM074999, R01GM056328)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- IP3 receptor, calcium release channel, endoplasmic reticulum, calcium signaling, channel gating, ligand-gated ion channels, channel structure, single-channel properties, signal transduction, calcium permeation
- MeSH terms
- Animals, Calcium, Electrophysiology, Humans, Calcium Channels, Ion Channel Gating, Calcium Signaling, Inositol 1,4,5-Trisphosphate Receptors
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