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Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations.
Open accessAbstract
lambda-Tris(3,4,7,8-tetramethyl-1,10-phenanthroline)ruthenium(II) [lambda-Ru(TMP)2+3] was found to be a distinctive molecular tool to examine the local variations in conformation along the strand. The metal complex binds cooperatively to A-form helices of various base sequences under conditions where little or no binding was found to analogous B-form DNAs. Photoactivated DNA cleavage may be coupled to this conformation-specific binding by taking advantage of the photophysical properties of ruthenium(II) complexes. lambda-Ru(TMP)2+3 cleaves preferentially 3H-labeled A-form polynucleotides upon irradiation with visible light. The photoinduced DNA strand scission is likely to be mediated by singlet oxygen, which leads to a preferential cleavage of guanine residues. Comparative mapping of cleavage sites on a linear pBR322 fragment for tris(phenanthroline)ruthenium(II), which binds to B-DNA and cleaves also by sensitization of singlet oxygen, and for Ru(TMP)2+3 shows the selective binding of lambda-Ru(TMP)2+3 to conformationally distinct sites along the fragment. These sites correspond to 5- to 13-base-pair homopyrimidine stretches.
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Cited by
Oxidative DNA damage through long-range electron transfer
Hall, D. B., Holmlin, R. E., & Barton, J. K. (1996) · Nature · doi:10.1038/382731a0 · Cited by 825
Self-citationPhotocleavage of Nucleic Acids
Armitage, B. (1998) · Chemical Reviews · doi:10.1021/cr960428+ · Cited by 688
Carbon—Hydrogen Bonds of DNA Sugar Units as Targets for Chemical Nucleases and Drugs
Pratviel, G., Bernadou, J., & Meunier, B. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199507461 · Cited by 422
Wilson, W. D., Ratmeyer, L., Zhao, M., Strekowski, L., & Boykin, D. (1993) · Biochemistry · doi:10.1021/bi00066a035 · Cited by 408
Wachter, E., Heidary, D. K., Howerton, B. S., Parkin, S., & Glazer, E. C. (2012) · Chemical Communications · doi:10.1039/c2cc33359g · Cited by 317
Metadata
- Authors
- Mei, H. Y., & Barton, J. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-03
- Volume
- 85
- Issue
- 5
- Pages
- 1339-1343
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017530901
- Cited by
- 179
- References
- 0
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations. https://app.cochat.ai/papers/10.1073/pnas.85.5.1339
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- Mei, H. Y., & Barton, J. K. (1988). Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.5.1339
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