The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window
Abstract
Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.
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Citations
Cites
Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1071 · Cited by 6,758
Ru(II) polypyridine complexes: photophysics, photochemistry, eletrochemistry, and chemiluminescence
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Single-strand break repair and genetic disease
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Photochemistry of tris(2,2'-bipyridine)ruthenium(2+) ion
Durham, B., Caspar, J. V., Nagle, J. K., & Meyer, T. J. (1982) · Journal of the American Chemical Society · doi:10.1021/ja00382a012 · Cited by 571
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine
Farrer, N. J., Salassa, L., & Sadler, P. J. (2009) · Dalton Transactions · doi:10.1039/b917753a · Cited by 496
A potent cytotoxic photoactivated platinum complex
Mackay, F. S., Woods, J. A., Heringová, P., Kašpárková, J., Pizarro, A. M., Moggach, S. A., Parsons, S., Brabec, V., & Sadler, P. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707742105 · Cited by 303
Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations.
Mei, H. Y., & Barton, J. K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1339 · Cited by 179
Photoinitiated DNA Binding by cis- [Ru(bpy) 2 (NH 3 ) 2 ] 2+
Singh, T. N., & Turró, C. (2004) · Inorganic Chemistry · doi:10.1021/ic049075k · Cited by 159
Light-induced cleavage of DNA by metal complexes
Fleisher, M. B., Waterman, K. C., Turro, N. J., & Barton, J. K. (1986) · Inorganic Chemistry · doi:10.1021/ic00240a001 · Cited by 145
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Zeng, L., Gupta, P., Chen, Y., Wang, E., Ji, L., Chao, H., & Chen, Z.-S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00195a · Cited by 1,017
Stimuli-Responsive Therapeutic Metallodrugs
Wang, X., Wang, X., Jin, S., Muhammad, N., & Guo, Z. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00209 · Cited by 649
Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy
Karges, J., Kuang, S., Maschietto, F., Blacque, O., Ciofini, I., Chao, H., & Gasser, G. (2020) · Nature Communications · doi:10.1038/s41467-020-16993-0 · Cited by 284
Metadata
- Authors
- Wachter, E., Heidary, D. K., Howerton, B. S., Parkin, S., & Glazer, E. C.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 48
- Issue
- 77
- Pages
- 9649
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2076221934
- Cited by
- 317
- References
- 13
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wachter, E., Heidary, D. K., Howerton, B. S., Parkin, S., & Glazer, E. C. (2012). Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window. Chemical Communications. https://doi.org/10.1039/c2cc33359g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
