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Cited by 408

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation.

Open access
Nohmi, T, Battista, J R, Dodson, L A, Walker, G C·1988·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.85.6.1816
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Abstract

The products of the SOS-regulated umuDC operon are required for most UV and chemical mutagenesis in Escherichia coli. It has been shown that the UmuD protein shares homology with LexA, the repressor of the SOS genes. In this paper we describe a series of genetic experiments that indicate that the purpose of RecA-mediated cleavage of UmuD at its bond between Cys-24 and Gly-25 is to activate UmuD for its role in mutagenesis and that the COOH-terminal fragment of UmuD is necessary and sufficient for the role of UmuD in UV mutagenesis. Other genetic experiments are presented that (i) support the hypothesis that the primary role of Ser-60 in UmuD function is to act as a nucleophile in the RecA-mediated cleavage reaction and (ii) raise the possibility that RecA has a third role in UV mutagenesis besides mediating the cleavage of LexA and UmuD.

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Metadata

Authors
Nohmi, T., Battista, J. R., Dodson, L. A., & Walker, G. C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1988-03
Volume
85
Issue
6
Pages
1816-1820
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.85.6.1816
OpenAlex
W2001952964
Cited by
408
References
33
FWCI
10.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. https://app.cochat.ai/papers/10.1073/pnas.85.6.1816
The paper
Nohmi, T., Battista, J. R., Dodson, L. A., & Walker, G. C. (1988). RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.6.1816

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.