Cited by 665DNA Repair MechanismsGenetic factors in colorectal cancerDNA and Nucleic Acid Chemistry

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

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Sale, Julian E., Lehmann, Alan R., Woodgate, Roger·2012·Nature Reviews Molecular Cell Biology

Abstract

The past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at the heart of this process, which is commonly known as translesion synthesis. This family of polymerases has unique features that enable them to synthesize DNA past damaged bases. However, as they exhibit low fidelity when copying undamaged DNA, it is essential that they are only called into play when they are absolutely required. Several layers of regulation ensure that this is achieved.

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  1. [107]Terai K Abbas T Jazaeri AA Dutta A CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis Mol. Cell 2010 37 143 149 20129063 PMC2818832

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Authors
Sale, J. E., Lehmann, A. R., & Woodgate, R.
Affiliations
  • MRC Laboratory of Molecular Biology (GB)
  • University of Sussex (GB)
  • National Institutes of Health (US)
Corresponding author
  • Sale, Julian E.
  • Lehmann, Alan R.
  • Woodgate, Roger
Venue
Nature Reviews Molecular Cell Biology
Published
2012-02-23
Volume
13
Issue
3
Pages
141-152
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1980745500
Cited by
665
References
135
Citations by year
2026: 26 · 2025: 28 · 2024: 38 · 2023: 30 · 2022: 35 · 2021: 41 · 2020: 55 · 2019: 36 · 2018: 37 · 2017: 62 · 2016: 59 · 2015: 59 · 2014: 75 · 2013: 48 · 2012: 35
FWCI
6.36
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD001500)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
Y-family DNA polymerases, translesion synthesis, DNA damage tolerance, DNA replication, mutagenesis, polymerase fidelity
MeSH terms
Animals, Bacterial Proteins, DNA Damage, DNA Repair, DNA Replication, Humans, Nucleotidyltransferases, Protein Binding, Mutagenesis, Protein Structure, Tertiary, Catalytic Domain

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