The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.
Open accessAbstract
The adhesion of thrombin-stimulated human blood platelets to either the endothelial surface of intact bovine aorta or cultured bovine aortic endothelial cells was studied to determine the role of endothelium-derived relaxing factor in the regulation of platelet adhesion. Endothelial cells and platelets were pretreated with indomethacin to prevent the formation of prostaglandins. The adhesion of thrombin-stimulated platelets to endothelial cells was reduced by superoxide dismutase and bradykinin. The inhibitory effect of both drugs was abolished by hemoglobin and was absent in strips of bovine aorta where the endothelial cells had been removed by scraping. It is suggested that the effects of bradykinin are mediated by the release of endothelium-derived relaxing factor, which is protected from destruction by superoxide dismutase, and that endothelium-derived relaxing factor contributes to the nonadhesive properties of the vascular endothelium.
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Mechanism of action of some inhibitors of endothelium-derived relaxing factor
Moncada, S., Palmer, R. M., & Gryglewski, R. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9164 · Cited by 219
Gryglewski, R. J., Moncada, S., & Palmer, R. M. J. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb14586.x · Cited by 200
Cited by
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.
Boulanger, C., & Lüscher, T. F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114477 · Cited by 1,045
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.006 · Cited by 343
Cominacini, L., Rigoni, A., Pasini, A. F., Garbin, U., Davoli, A., Campagnola, M., Pastorino, A. M., Lo Cascio, V., & Sawamura, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010612200 · Cited by 340
Metadata
- Authors
- Sneddon, J. M., & Vane, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-04
- Volume
- 85
- Issue
- 8
- Pages
- 2800-2804
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026021985
- Cited by
- 260
- References
- 3
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Sneddon, J. M., & Vane, J. R. (1988). Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.8.2800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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