Characterization of human cardiac myosin heavy chain genes.

Yamauchi-Takihara, K; Sole, M J; Liew, J; Ing, D; Liew, C C

doi:10.1073/pnas.86.10.3504

Cited by 103Cardiomyopathy and Myosin StudiesMuscle Physiology and DisordersCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Characterization of human cardiac myosin heavy chain genes.

Open access

Yamauchi-Takihara, K, Sole, M J, Liew, J, Ing, D, Liew, C C·1989·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.86.10.3504PMC PMC298074

Open this paper in CoChat — free account

Abstract

We have isolated and analyzed the structure of the genes coding for the alpha and beta forms of the human cardiac myosin heavy chain (MYHC). Detailed analysis of four overlapping MYHC genomic clones shows that the alpha-MYHC and beta-MYHC genes constitute a total length of 51 kilobases and are tandemly linked. The beta-MYHC-encoding gene, predominantly expressed in the normal human ventricle and also in slow-twitch skeletal muscle, is located 4.5 kilobases upstream of the alpha-MYHC-encoding gene, which is predominantly expressed in normal human atrium. We have determined the nucleotide sequences of the beta form of the MYHC gene, which is 100% homologous to the cardiac MYHC cDNA clone (pHMC3). It is unlikely that the divergence of a few nucleotide sequences from the cardiac beta-MYHC cDNA clone (pHMC3) reported in a MYHC cDNA clone (pSMHCZ) from skeletal muscle is due to a splicing mechanism. This finding suggests that the same beta form of the cardiac MYHC gene is expressed in both ventricular and slow-twitch skeletal muscle. The promoter regions of both alpha- and beta-MYHC genes, as well as the first four coding regions in the respective genes, have also been sequenced. The sequences in the 5'-flanking region of the alpha- and beta-MYHC-encoding genes diverge extensively from one another, suggesting that expression of the alpha- and beta-MYHC genes is independently regulated.

Integrity signals

Registry

Crossref · 10.1073/pnas.86.10.3504

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A high similarity in amino acid sequences between 2 human MyHC isoforms (93%) has been identified.
“Supporting this, a high similarity in amino acid sequences between 2 human MyHC isoforms (93%) has been identified. 47,280,281”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [280]

The isolation of structural genes from libraries of eucaryotic DNA
Maniatis, T., Hardison, R. C., Lacy, E., Lauer, J., O'Connell, C., Quon, D. H., Sim, G.-K., & Efstratiadis, A. (1978) · Cell · doi:10.1016/0092-8674(78)90036-3 · Cited by 1,826
Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement
Hoh, J. (1978) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(78)90401-7 · Cited by 770
Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.
Lompré, A., Nadal-Ginard, B., & Mahdavi, V. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82162-0 · Cited by 615
Myosin isoenzyme redistribution in chronic heart overload
Lompré, A., Schwartz, K., d’Albis, A., Lacombe, G., Thiem, N. V., & Bernard Swynghedauw, A. (1979) · Nature · doi:10.1038/282105a0 · Cited by 523
Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.
Mahdavi, V., Chambers, A. P., & Nadal-Ginard, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2626 · Cited by 328
[58] DNA sequence analysis by primed synthesis
Smith, A. J. H. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65060-5 · Cited by 280
Molecular characterization of two myosin heavy chain genes expressed in the adult heart
Mahdavi, V., Periasamy, M., & Nadal‐Ginard, B. (1982) · Nature · doi:10.1038/297659a0 · Cited by 278
Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene
Strehler, E. E., Strehler-Page, M. A., Perriard, J., Periasamy, M., & Nadal‐Ginard, B. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90003-3 · Cited by 264
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family.
Mahdavi, V., Izumo, S., & Nadal-Ginard, B. (1987) · Circulation Research · doi:10.1161/01.res.60.6.804 · Cited by 202
Human cardiac myosin heavy chain genes and their linkage in the genome
Sáez, L., Gianola, K. M., McNally, E. M., Feghali, R., Eddy, R. L., Shows, T. B., & Leinwand, L. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5443 · Cited by 165
Myosin types in the human heart. An immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium.
Gorza, L., Mercadier, J.-J., Schwartz, K., Thornell, L., Sartore, S., & Schiaffino, S. (1984) · Circulation Research · doi:10.1161/01.res.54.6.694 · Cited by 162
Characterization of sarcomeric myosin heavy chain genes.
Wydro, R., Nguyen, H. T., Gubits, R. M., & Nadal‐Ginard, B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33307-6 · Cited by 134
Molecular cloning of mRNA sequences for cardiac alpha- and beta-form myosin heavy chains: expression in ventricles of normal, hypothyroid, and thyrotoxic rabbits.
Sinha, A. M., Umeda, P. K., Kavinsky, C. J., Rajamanickam, C., Hsu, H. J., Jakovcic, S., & Rabinowitz, M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.19.5847 · Cited by 131
The sequence of the NH2-terminal 204-residue fragment of the heavy chain of rabbit skeletal muscle myosin.
Tong, S. W., & Elzinga, M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44086-5 · Cited by 128
Change in synthesis rates of alpha- and beta-myosin heavy chains in rabbit heart after treatment with thyroid hormone.
Everett, A. W., Clark, W. A., Chizzonite, R., & Zak, R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32942-9 · Cited by 97
Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle
Sáez, L., & Leinwand, L. A. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.7.2951 · Cited by 96
Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.
Kurabayashi, M., Tsuchimochi, H., Komuro, I., Takaku, F., & Yazaki, Y. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113627 · Cited by 81
Isolation of multiple genomic sequences coding for chicken myosin heavy chain protein.
Robbins, J. M., Freyer, G. A., Chisholm, D. A., & Gilliam, T. C. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68399-7 · Cited by 74
Cloned mRNA sequences for two types of embryonic myosin heavy chains from chick skeletal muscle. II. Expression during development using S1 nuclease mapping.
Umeda, P. K., Kavinsky, C. J., Sinha, A. M., Hsu, H. J., Jakovcic, S., & Rabinowitz, M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32559-6 · Cited by 62
Two different forms of beta myosin heavy chain are expressed in human striated muscle
Jandreski, M. A., Sole, M. J., & Liew, C.-C. (1987) · Human Genetics · doi:10.1007/bf00272378 · Cited by 45
Self-citation
Partial characterization of the human β‐myosin heavy‐chain gene which is expressed in heart and skeletal muscle
Lichter, P., Umeda, P. K., Levin, J. E., & Vosberg, H.-P. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09989.x · Cited by 41
Characterization of genomic clones specifying rabbit alpha- and beta-ventricular myosin heavy chains.
Friedman, D. J., Umeda, P. K., Sinha, A. M., Hsu, H. J., Jakovcic, S., & Rabinowitz, M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.10.3044 · Cited by 36
Construction and characterization of the alpha form of a cardiac myosin heavy chain cDNA clone and its developmental expression in the Syrian hamster.
Liew, C., & Jandreski, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.10.3175 · Cited by 18
Self-citation
Construction of a human ventricular cDNA library and characterization of a beta myosin heavy chain cDNA clone
Jandreski, M. A., & Liew, C. (1987) · Human Genetics · doi:10.1007/bf00283049 · Cited by 16
Self-citation
Human cardiac myosin heavy chain genes. Isolation of a genomic DNA clone and its characterization and of a second unique clone also present in the human genome.
Catanzaro, D. F., & Morris, B. J. (1986) · Circulation Research · doi:10.1161/01.res.59.6.655 · Cited by 9

Flagged first, then by citations

Sorted by citations

Regulation of Contraction in Striated Muscle
Gordon, A. M., Homsher, E. E., & Regnier, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.2.853 · Cited by 1,740
A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
Geisterfer-Lowrance, A. A. T., Kass, S., Tanigawa, G., Vosberg, H.-P., McKenna, W., Seidman, C. E., & Seidman, J. G. (1990) · Cell · doi:10.1016/0092-8674(90)90274-i · Cited by 1,380
Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.
Subramaniam, A., Jones, W. K., Gulick, J. M., Wert, S. E., Neumann, J. C., & Robbins, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54273-3 · Cited by 470
Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.
Caforio, A. L., Grazzini, M., Mann, J. M., Keeling, P. J., Bottazzo, G. F., McKenna, W. J., & Schiaffino, S. (1992) · Circulation · doi:10.1161/01.cir.85.5.1734 · Cited by 315
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy
Kunisada, K., Negoro, S., Tone, E., Funamoto, M., Osugi, T., Yamada, S., Okabe, M., Kishimoto, T., & Yamauchi‐Takihara, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.315 · Cited by 274
Self-citation
Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice
Tomizuka, K., Yoshida, H., Uejima, H., Kugoh, H., Sato, K., Ohguma, A., Hayasaka, M., Hanaoka, K., Oshimura, M., & Ishida, I. (1997) · Nature Genetics · doi:10.1038/ng0697-133 · Cited by 267
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.
Ng, W. A., Grupp, I. L., Subramaniam, A., & Robbins, J. M. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1742 · Cited by 231
A molecular basis for familial hypertrophic cardiomyopathy: An αβ cardiac myosin heavy chain hybrid gene
Tanigawa, G., Jarcho, J. A., Kass, S., Solomon, S. D., Vosberg, H.-P., Seidman, J. G., & Seidman, C. E. (1990) · Cell · doi:10.1016/0092-8674(90)90273-h · Cited by 223
Skeletal muscle injury induced by eccentric muscle action: muscle proteins as markers of muscle fiber injury.
Sorichter, S., Puschendorf, B., & Mair, J. (1999) · PubMed · Cited by 200
Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific
Smith, K. P., Moen, P. T., Wydner, K. L., Coleman, J. R., & Lawrence, J. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.617 · Cited by 191
The complete sequence of the human β-myosin heavy chain gene and a comparative analysis of its product
Jaenicke, T., Diederich, K. W., Haas, W., Schleich, J., Lichter, P., Pfordt, M., Bach, A., & Vosberg, H.-P. (1990) · Genomics · doi:10.1016/0888-7543(90)90272-v · Cited by 179
Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.
Robbins, J. M., Gulick, J. M., Sanchez, A., Howles, P. N., & Doetschman, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38485-6 · Cited by 172
Cardiac Troponin T in the Diagnosis of Myocardial Injury
Mair, J. M., Dienstl, F., & Puschendorf, B. (1992) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369209105245 · Cited by 158
Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.
Tsika, R. W., Bahl, J. J., Leinwand, L. A., & Morkin, E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.379 · Cited by 146
Progress in Myocardial Damage Detection: New Biochemical Markers for Clinicians
Mair, J. M., & Apple, F. S. (1997) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369709038215 · Cited by 143
Demonstration of ?cardiac-specific? myosin heavy chain in masticatory muscles of human and rabbit
Bredman, J. J., Wessels, A., Weijs, W. A., Korfage, J. A. M., Soffers, C. A. S., & Moorman, A. F. M. (1991) · The Histochemical Journal · doi:10.1007/bf01046587 · Cited by 138
Physical Interaction between TBX5 and MEF2C Is Required for Early Heart Development
Ghosh, T. K., Song, F., Packham, E. A., Buxton, S., Robinson, T. E., Ronksley, J., Self, T. J., Bonser, A. J., & Brook, J. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01923-08 · Cited by 136
Complete sequence and organization of the human cardiac β-myosin heavy chain gene
Liew, C.-C., Sole, M. J., Yamauchi‐Takihara, K., Kellam, B., Anderson, D., Lin, L., & Liew, J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3647 · Cited by 130
Self-citation
Efficient Transfer of Genes into Murine Cardiac Grafts by Starburst Polyamidoamine Dendrimers
Qin, L., Pahud, D. R., Ding, Y., Bielinska, A. U., Kukowska‐Latallo, J. F., Baker, J. R., & Bromberg, J. S. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.4-553 · Cited by 124
Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.
Sánchez, A., Jones, W. K., Gulick, J. M., Doetschman, T., & Robbins, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54589-0 · Cited by 122
In vivo analysis of the murine beta-myosin heavy chain gene promoter.
Rindt, H., Gulick, J. M., Knotts, S., Neumann, J. C., & Robbins, J. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53537-7 · Cited by 121
Cardiac troponin I in the diagnosis of myocardial injury and infarction
Mair, J. M., Genser, N., Morandell, D., Maier, J., Mair, P., Lechleitner, P., Calzolari, C., Larue, C., Ambach, E., Dienstl, F., et al. (1996) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06168-1 · Cited by 121
Sarcomeric protein isoform transitions in cardiac muscle: A journey to heart failure
Yin, Z., Ren, J. T., & Guo, W. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.11.003 · Cited by 115
Molecular and cellular mechanisms involved in the generation of fiber diversity during myogenesis
Wigmore, P. M., & Evans, D. J. R. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)16006-2 · Cited by 113
Evidence for three adult fast myosin heavy chain isoforms in type II skeletal muscle fibers in pigs.
Lefaucheur, L., Hoffman, R. K., Gerrard, D. E., Okamura, C. S., Rubinstein, N. A., & Kelly, A. M. (1998) · Journal of Animal Science · doi:10.2527/1998.7661584x · Cited by 110
Gene and Locus Structure and Chromosomal Localization of the Protease-activated Receptor Gene Family
Kahn, M. L., Hammes, S. R., Botka, C. W., & Coughlin, S. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23290 · Cited by 106
Cardiac troponin I and troponin T: Are enzymes still relevant as cardiac markers?
Mair, J. M. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(96)06436-4 · Cited by 104
Contractile protein mutations and heart disease
Vikstrom, K. L., & Leinwand, L. A. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80053-6 · Cited by 104
Mutations of the β myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis
Woo, A., Rakowski, H., Liew, J. C., Zhao, M.-S., Liew, C.-C., Parker, T. G., Zeller, M., Wigle, E. D., & Sole, M. J. (2003) · Heart · doi:10.1136/heart.89.10.1179 · Cited by 98
Self-citation
Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos
Logan, M., & Mohun, T. J. (1993) · Development · doi:10.1242/dev.118.3.865 · Cited by 97
Interaction of thyroid hormone receptors with strong and weak cis-acting elements in the human alpha-myosin heavy chain gene promoter.
Flink, I. L., & Morkin, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38581-3 · Cited by 94
Repositioning of Muscle-specific Genes Relative to the Periphery of SC-35 Domains during Skeletal Myogenesis
Moen, P. T., Johnson, C. V., Byron, M., Shopland, L. S., de la Serna, I. L., Imbalzano, A. N., & Lawrence, J. B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0388 · Cited by 93
Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter.
Subramaniam, A., Gulick, J. M., Neumann, J. C., Knotts, S., & Robbins, J. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53614-0 · Cited by 91
Characterization of a strong positive cis-acting element of the human beta-myosin heavy chain gene in fetal rat heart cells.
Flink, I. L., Edwards, J. G., Bahl, J. J., Liew, C. C., Sole, M., & Morkin, E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50180-6 · Cited by 87
Self-citation
Antibodies Against Myosin in Sera of Patients with Idiopathic Paroxysmal Atrial Fibrillation
Maixent, J. M., Paganelli, F. F., Scaglione, J., & Lévy, S. (1998) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1998.tb00942.x · Cited by 84
Biologically improved nanofibrous scaffolds for cardiac tissue engineering
Bhaarathy, V., Venugopal, J. R., Gandhimathi, C., Ponpandian, N., Mangalaraj, D., & Ramakrishna, S. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.08.018 · Cited by 81
Cardiac myocytes and dendritic cells harbor human immunodeficiency virus in infected patients with and without cardiac dysfunction: Detection by multiplex, nested, polymerase chain reaction in individually microdissected cells from right ventricular endomyocardial biopsy tissue
Rodríguez, E. R., Nasim, S., Hsia, J. A., Sandin, R. L., Ferreira, A., Hilliard, B. A., Ross, A. M., & Garrett, C. T. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90288-v · Cited by 78
Evaluation of the Biocompatibility of PLACL/Collagen Nanostructured Matrices with Cardiomyocytes as a Model for the Regeneration of Infarcted Myocardium
Mukherjee, S., Venugopal, J. R., Ravichandran, R., Ramakrishna, S., & Raghunath, M. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201002434 · Cited by 71
A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12.
Solomon, S. D., Geisterfer-Lowrance, A. A. T., Vosberg, H.-P., Hiller, G., Jarcho, J. A., Morton, C. C., McBride, W. O., Mitchell, A. L., Bale, A. E., & McKenna, W. J. (1990) · PubMed · Cited by 70
Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton
Oh, S. W., Pope, R. K., Smith, K. P., Crowley, J. L., Nebl, T., Lawrence, J. B., & Luna, E. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00422 · Cited by 63
Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced β-myosin heavy chain gene expression and cardiomyocyte hypertrophy
Cheng, T., Shih, N., Chen, C., Lin, H., Liu, J., Chao, H., Liou, J.-Y., Chen, Y., Tsai, H.-W., Chen, Y.-S., et al. (2005) · Journal of Biomedical Science · doi:10.1007/s11373-004-8168-6 · Cited by 58
MYH7 in cardiomyopathy and skeletal muscle myopathy
Gao, Y., Peng, L., & Zhao, C. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04735-x · Cited by 57
Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart
Warkman, A. S., Whitman, S. A., Miller, M. K., Garriock, R. J., Schwach, C. M., Gregorio, C. C., & Krieg, P. A. (2012) · Cytoskeleton · doi:10.1002/cm.21029 · Cited by 53
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene.
Adolph, E., Subramaniam, A., Cserjesi, P., Olson, E. N., & Robbins, J. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53326-3 · Cited by 50
Molecular Characterization and Developmental Expression ofNORPEG, a Novel Gene Induced by Retinoic Acid
Kutty, R. K., Kutty, G., Samuel, W., Duncan, T. E., Bridges, C. C., El-Sherbeny, A., Nagineni, C. N., Smith, S. B., & Wiggert, B. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007421200 · Cited by 46
Tissue-Restricted Expression of the Cardiac α-Myosin Heavy Chain Gene Is Controlled by a Downstream Repressor Element Containing a Palindrome of Two Ets-Binding Sites
Gupta, M., Zak, R., Libermann, T. A., & Gupta, M. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7243 · Cited by 46
Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart
Guo, W., Zhu, C., Yin, Z., Wang, Q., Sun, M., Cao, H., & Greaser, M. L. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.24117 · Cited by 43
Fabrication of superparamagnetic nano-silica@ quercetin-encapsulated PLGA nanocomposite: Potential application for cardiovascular diseases
Wang, L., Feng, M., Li, Y., Du, Y., Wang, H., Chen, Y., & Li, L. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.05.005 · Cited by 43
Clinical Significance of Cardiac Contractile Proteins for the Diagnosis of Myocardial Injury
Mair, J. M., Puschendorf, B., & Michel, G. (1994) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60333-9 · Cited by 43
Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol
van Dartel, D. A. M., Zeijen, N. J. L., de la Fonteyne, L. J. J., van Schooten, F., & Piersma, A. H. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.03.017 · Cited by 42
Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development.
Maggs, A. M., Taylor-Harris, P. M., Peckham, M., & Hughes, S. M. (2000) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1005639229497 · Cited by 42
Cis-acting elements responsible for muscle-specific expression of the myosin heavy chain β gene
Shimizu, N., Prior, G., Umeda, P. K., & Zak, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.7.1793 · Cited by 42
Identification of a Novel Autoantigen UACA in Patients with Panuveitis
Yamada, K., Senju, S., Nakatsura, T., Murata, Y., Ishihara, M., Nakamura, S., Ohno, S., Negi, A., & Nishimura, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4189 · Cited by 39
Proliferation and Maturation: Janus and the Art of Cardiac Tissue Engineering
Singh, B. N., Yücel, D., Garay, B. I., Tolkacheva, E. G., Kyba, M., Perlingeiro, R. C. R., van Berlo, J. H., & Ogle, B. M. (2023) · Circulation Research · doi:10.1161/circresaha.122.321770 · Cited by 40
Complete sequence of human cardiac α‐myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences
Matsuoka, R., Beisel, K. W., Furutani, M., Arai, S., & Takao, A. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320410435 · Cited by 38
Autoimmunity in Chagas' heart disease
Cunha‐Neto, E., & Kalil, J. E. (1995) · Sao Paulo Medical Journal · doi:10.1590/s1516-31801995000200005 · Cited by 37
Emulsion electrospun nanofibers as substrates for cardiomyogenic differentiation of mesenchymal stem cells
Tian, L., Prabhakaran, M. P., Ding, X. B., Kai, D., & Ramakrishna, S. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-5003-5 · Cited by 34
Different time courses of cardiac contractile proteins after acute myocardial infarction
Mair, J. M., Wagner, I. M., Jakob, G., Lechleitner, P., Dienstl, F., Puschendorf, B., & Michel, G. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90253-4 · Cited by 34
Subcellular compartmentalization of myosin isoforms in embryonic chick heart ventricle myocytes during cytokinesis
Conrad, A. H., Clark, W. A., & Conrad, G. W. (1991) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970190307 · Cited by 34
The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart.
Tsoporis, J. N., Marks, A., Zimmer, D. B., McMahon, C., & Parker, T. G. (2003) · PubMed · Cited by 33
Structural organization of the human cardiac α-myosin heavy chain gene (MYH6)
Epp, T. A., Dixon, I., Wang, H.-Y., Sole, M. J., & Liew, C. (1993) · Genomics · doi:10.1016/s0888-7543(11)80006-6 · Cited by 32
Self-citation
Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis
Luukko, K., Arumäe, U., Karavanov, A. A., Moshnyakov, M., Sainio, K., Sariola, H. V., Saarma, M., & Thesleff, I. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199710)210:2 · Cited by 70
The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart
Tsoporis, J. N., Marks, A., Zimmer, D. B., McMahon, C., & Parker, T. G. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1021148503861 · Cited by 31
S100A6 is a negative regulator of the induction of cardiac genes by trophic stimuli in cultured rat myocytes
Tsoporis, J. N., Marks, A., Haddad, A., O'Hanlon, D., Jolly, S., & Parker, T. G. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.018 · Cited by 27
In vivo expression and molecular characterization of the porcine slow myosin heavy chain
Chang, K., Fernandes, K., & Goldspink, G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.1.331 · Cited by 27
Developmental expression and comparative genomic analysis of Xenopus cardiac myosin heavy chain genes
Garriock, R. J., Meadows, S. M., & Krieg, P. A. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20460 · Cited by 26
Muscular adaptation and strength during the early phase of eccentric training: influence of the training frequency
Sorichter, S., Mair, J., Koller, A., Sečník, P., Parrák, V., Haid, C., LLER, E. M., & Puschendorf, B. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199712000-00015 · Cited by 26
Characterization of the allelic differences in the mouse cardiac α-myosin heavy chain coding sequence
Quinn-Laquer, B. K., Kennedy, J. E., Wei, S. J., & Beisel, K. W. (1992) · Genomics · doi:10.1016/0888-7543(92)90218-h · Cited by 25
Human embryonic myosin heavy chain cDNA
Eller, M. S., Stedman, H. H., Sylvester, J. E., Fertels, S. H., Wu, Q., Raychowdhury, M. K., Rubinstein, N. A., Kelly, A. M., & Sarkar, S. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81710-7 · Cited by 23
Presence of cardiac ?-myosin correlates with histochemical myosin Ca2+ ATPase activity in rabbit masseter muscle
Bredman, J. J., Weijs, W. A., & Moorman, A. F. M. (1992) · The Histochemical Journal · doi:10.1007/bf01046840 · Cited by 21
Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels
Yang, Y., Hao, Z., An, N., Han, Y., Miao, W., Storey, K. B., Lefai, É., Liu, X., Wang, J., Liu, S., et al. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31123 · Cited by 18
Characterization of the GArC motif. A novel cis-acting element of the human cardiac myosin heavy chain genes.
Mably, J. D., Sole, M. J., & Liew, C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54176-4 · Cited by 17
Self-citation
Article Commentary: Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes
Schwan, J., & Campbell, S. G. (2015) · Biomarker Insights · doi:10.4137/bmi.s23912 · Cited by 21
Functional Segregation within the Muscles of Aquatic Propulsion in the Asiatic Water Monitor (Varanus salvator)
Young, B. A., Dumais, J., John, N., Lyons, B., Macduff, A., Most, M., Reiser, N. A., & Reiser, P. J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00380 · Cited by 15
No evidence for linkage of familial hypertrophic cardiomyopathy and chromosome 14q1 locus D14S26 in a chinese family: evidence for genetic heterogeneity
Ko, Y., Lien, W.-P., Chen, J.-J., Wu, C.-W., Tang, T. K., & Liew, C.-C. (1992) · Human Genetics · doi:10.1007/bf00221945 · Cited by 14
Self-citation
Expression of human β-myosin heavy chain fragments inEscherichia coli; localization of actin interfaces on cardiac myosin
Eldin, P., Cunff, M. L., Diederich, K. W., Jaenicke, T., Cornillon, B., Mornet, D., Vosberg, H.-P., & Leger, J. J. (1990) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf01739759 · Cited by 13
The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model
Zhang, Z., Xiang, L., Zhao, L.-P., Jiao, H., Wang, Z., Li, Y., & Chen, Y. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2311-9 · Cited by 11
Myosin individualized: single nucleotide polymorphisms in energy transduction
Burghardt, T. P., Neff, K. L., Wieben, E. D., & Ajtai, K. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-172 · Cited by 11
Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo
Zilberman‐Rudenko, J., Deguchi, H., Shukla, M., Oyama, Y., Orje, J. N., Guo, Z., Wyseure, T. L., Mosnier, L. O., McCarty, O. J. T., Ruggeri, Z. M., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.313990 · Cited by 9
A Missense Mutation in the .BETA.-Myosin Heavy Chain Gene in a Japanese Patient With Hypertrophic Cardiomyopathy.
Nakajima-Taniguchi, C., Azuma, J., Nagata, S., Kishimoto, T., & Yamauchi‐Takihara, K. (1995) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.59.833 · Cited by 9
Self-citation
Sarcomeric Gene Variants and Their Role with Left Ventricular Dysfunction in Background of Coronary Artery Disease
Kumar, S., Kumar, V., & Kim, J.-J. (2020) · Biomolecules · doi:10.3390/biom10030442 · Cited by 7
Effect of human endothelial cells on Human Bone Marrow Stromal Cell phenotype: Role of VEGF?
Villars, F., Bordenave, L., Bareille, R., & Am�d�e, J. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20001215)79:4 · Cited by 224
Regulation of Human Cardiac Myosin Heavy Chain Gene Expression by Thyroid Hormone
Morkin, E., Edwards, J. G., Tsika, R. W., Bahl, J. J., & Flink, I. L. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-6015-5_12 · Cited by 5
Cardiac myosin heavy chain expression during heart development in Xenopus laevis
Cox, W. G., & Neff, A. W. (1995) · Differentiation · doi:10.1046/j.1432-0436.1995.5840269.x · Cited by 5
Regulation of human cardiac myosin heavy chain genes: The effect of catecholamine
Chen, J. J., Wang, D. L., Shih, N. L., Hsu, K.-H., Lien, W. P., & Liew, C. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91090-d · Cited by 4
Self-citation
Which skeletal myoblasts and how to be transplanted for cardiac repair?
Tezuka, A., Kawada, T., Nakazawa, M., Masui, F., Konno, S., Nitta, S., & Toyo‐oka, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.084 · Cited by 3
The regulation of the human β myosin heavy-chain gene
Vosberg, H.-P., Horstmann-Herold, U., & Wettstein, A. (1992) · Steinkopff eBooks · doi:10.1007/978-3-642-72474-9_13 · Cited by 3
Gene assignment in the spider monkey (Ateles paniscus chamek-APC): APE-MYH7 to 2q; AR-GLA-F8C to the X chromosome
Canavez, F. (1999) · Journal of Heredity · doi:10.1093/jhered/90.4.460 · Cited by 3
The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart
Tsoporis, J. N., Marks, A., Zimmer, D. B., McMahon, C., & Parker, T. G. (2003) · Springer eBooks · doi:10.1007/978-1-4757-4712-6_4 · Cited by 2
The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations
Joyce, W. (2025) · Physiology · doi:10.1152/physiol.00021.2025 · Cited by 1
Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin‐dependent anticoagulant activity
Morla, S., Deguchi, H., & Griffin, J. H. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15169 · Cited by 1
Serial deletion constructs of human cardiac myosin heavy chain genes generated by PCR amplification
Chen, J. J., Shih, N. L., Hsu, K. H., & Liew, C. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01096384 · Cited by 1
Self-citation
Detection of developmental toxicity using differentiating embryonic stem cells : a transcriptomic approach
van Dartel, D. A. M. (2011) · doi:10.26481/dis.20111014dd
The Gene in the Twenty‐First Century
Liew, C., & Dzau, V. J. (2007) · Wiley eBooks · doi:10.1002/9780470691977.ch1
Self-citation
The regulation of the human fJ myosin heavy-chain gene
Horstmann-Herold, U., & Wettstein, A. (1992)
Chromosome 14
Donlon, T. A. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0709
GENETICS OF CARDIOMYOPATHY
Kurtović-Kozarić, A. (2021) · doi:10.5644/pi2021.199.01
Knockdown of LOX-1 ameliorates cardiac hypertrophy in alcoholic cardiomyopathy via inactivating the p38MAPK pathwayPreprint
Zhang, Y., Yuan, B., Xu, Y., Zhou, N., Wang, X., Lv, X., & Feng, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4733824/v1
Ohno-miRNAs: intragenic miRNA pairs derived from whole-genome duplicationPreprint
Agasso, L., Molineris, I., & Caselle, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.16.632905

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.
Mahdavi, V., Chambers, A. P., & Nadal-Ginard, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2626 · Cited by 328
Two different forms of beta myosin heavy chain are expressed in human striated muscle
Jandreski, M. A., Sole, M. J., & Liew, C.-C. (1987) · Human Genetics · doi:10.1007/bf00272378 · Cited by 45
Self-citation
Human cardiac myosin heavy chain genes and their linkage in the genome
Sáez, L., Gianola, K. M., McNally, E. M., Feghali, R., Eddy, R. L., Shows, T. B., & Leinwand, L. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5443 · Cited by 165
Partial characterization of the human β‐myosin heavy‐chain gene which is expressed in heart and skeletal muscle
Lichter, P., Umeda, P. K., Levin, J. E., & Vosberg, H.-P. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09989.x · Cited by 41
The Promoter of the Human Cardiac β-Myosin Heavy-Chain Gene Is Controlled by an Upstream Enhancer
Wettstein, A., & Vosberg, H.-P. (1993) · Springer eBooks · doi:10.1007/978-3-642-77891-9_5

Authors: Yamauchi-Takihara, K., Sole, M. J., Liew, J., Ing, D., & Liew, C. C.
Affiliations: Department of Medicine, Max Bell Research Center, Toronto General Hospital, University of Toronto, ON, Canada.
University of Toronto (CA)
ORCID: Liew, J
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1989-05
Volume: 86
Issue: 10
Pages: 3504-3508
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.86.10.3504
PMC: PMC298074
OpenAlex: W2066873880
Cited by: 103
References: 25
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 10.84
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: cardiac myosin heavy chain, gene structure, promoter, 5'-flanking region, slow-twitch muscle, ventricular myocardium, atrial muscle, gene expression regulation, alternative splicing
MeSH terms: Amino Acid Sequence, Base Sequence, Cloning, Molecular, Genes, Humans, Molecular Sequence Data, Myocardium, Myosins, Blotting, Southern, Restriction Mapping

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterization of human cardiac myosin heavy chain genes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks