The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.
Open accessAbstract
Two-dimensional NMR has been used to study the 2:1 distamycin A.d(CGCAAATTGGC).d(GCCAATTTGCG) complex. The nuclear Overhauser effect spectroscopy (NOESY) experiment was used to assign the aromatic and C1'H DNA protons and to identify drug-DNA contacts. These data indicate that two drug molecules bind simultaneously in the minor groove of the central 5'-AAATT-3' segment and are in close contact with both the DNA and one another. One drug binds with the formyl end close to the second adenine base of the A-rich strand, while the other drug binds with the formyl end close to the second adenine of the complementary strand. With this binding orientation, the positively charged propylamidinium groups are directed toward opposite ends of the helix. Molecular modeling shows that the minor groove must expand relative to the 1:1 complex to accommodate both drugs. Energy calculations suggest that electrostatic interactions, hydrogen bonds, and van der Waals forces contribute to the stability of the complex.
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Cites
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
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Self-citationStructure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution
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Cited by
Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids
Baird, E. E., & Dervan, P. B. (1996) · Journal of the American Chemical Society · doi:10.1021/ja960720z · Cited by 360
Bailly, C., & Chaires, J. B. (1998) · Bioconjugate Chemistry · doi:10.1021/bc980008m · Cited by 254
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58
Metadata
- Authors
- Pelton, J. G., & Wemmer, D. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 15
- Pages
- 5723-5727
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011475362
- Cited by
- 393
- References
- 23
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR. https://app.cochat.ai/papers/10.1073/pnas.86.15.5723
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- Pelton, J. G., & Wemmer, D. E. (1989). Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.15.5723
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
