The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.
Open accessAbstract
Two types of binding sites have previously been described for 36-amino acid neuropeptide Y (NPY), called Y1 and Y2 receptors. Y2 receptors can bind long C-terminal fragments of NPY-e.g., NPY-(13-36)-peptide. In contrast, Y1 receptors have until now only been characterized as NPY receptors that do not bind such fragments. In the present study an NPY analog is presented, [Leu31, Pro34]NPY, which in a series of human neuroblastoma cell lines and on rat PC-12 cells can displace radiolabeled NPY only from cells that express Y1 receptors and not from those expressing Y2 receptors. The radiolabeled analog, [125I-Tyr36] monoiodo-[Leu31, Pro34]NPY, also binds specifically only to cells with Y1 receptors. The binding of this analog to Y1 receptors on human neuroblastoma cells is associated with a transient increase in cytoplasmic free calcium concentrations similar to the response observed with NPY. [Leu31, Pro34]NPY is also active in vivo as it is even more potent than NPY in increasing blood pressure in anesthetized rats. It is concluded that [Leu31, Pro34]NPY is a specific Y1 receptor agonist and that the analog or variants of it can be useful in delineating the physiological importance of Y1 receptors.
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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,607
Polazzi, E., Mengoni, I., Caprini, M., Peña-Altamira, E., Kurtys, E., & Monti, B. (2013) · Neurosignals · doi:10.1159/000337115 · Cited by 8,994
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
Kaiser, E., Colescott, R. L., Bossinger, C. D., & Cook, P. I. (1970) · Analytical Biochemistry · doi:10.1016/0003-2697(70)90146-6 · Cited by 3,516
Neuropeptide Y: complete amino acid sequence of the brain peptide.
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5485 · Cited by 1,378
Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction
Sarin, V. K., Kent, S. B. H., Tam, J. P., & Merrifield, R. B. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90704-1 · Cited by 1,065
Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides
Wahlestedt, C., Yanaihara, N., & Håkanson, R. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90048-0 · Cited by 631
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2514 · Cited by 612
Pancreatic Polypeptide: A Hormone Under Vagal Control
Schwartz, T. W. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80027-4 · Cited by 426
Self-citationNeuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons
Walker, M., Ewald, D., Perney, T., & Miller, R. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02438.1988 · Cited by 207
Y1 and Y2 receptors for neuropeptide Y
Sheikh, S. P., Håkanson, R., & Schwartz, T. W. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80223-6 · Cited by 184
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Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
The NPY system in stress, anxiety and depression
Heilig, M. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 614
Cloned human neuropeptide Y receptor couples to two different second messenger systems.
Herzog, H., Hort, Y. J., Ball, H. J., Hayes, G., Shine, J., & Selbie, L. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5794 · Cited by 434
Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.
Larhammar, D., Blomqvist, A. G., Yee, F., Jazin, E., Yoo, H., & Wahlested, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49854-2 · Cited by 422
Regional distribution of Y‐receptor subtype mRNAs in rat brain
Parker, R. M. C., & Herzog, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00553.x · Cited by 411
Metadata
- Authors
- Fuhlendorff, J., Gether, U., Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, O., & Schwartz, T. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-01
- Volume
- 87
- Issue
- 1
- Pages
- 182-186
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2092743131
- Cited by
- 375
- References
- 18
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Fuhlendorff, J., Gether, U., Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, O., & Schwartz, T. W. (1990). [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.1.182
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