The DOI matches its Crossref record.
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.
Open accessAbstract
Defensins are cationic, cysteine-rich peptides (Mr = 3500-4000) found in the cytoplasmic granules of neutrophils and macrophages. These peptides possess broad antimicrobial activity in vitro against bacteria, fungi, tumor cells, and enveloped viruses, and they are believed to contribute to the "oxygen-independent" antimicrobial defenses of neutrophils and macrophages. Pathophysiologic studies in vitro have pointed to the plasma membrane as a possible target for the cytotoxic action of defensins. We report here that defensins form voltage-dependent, weakly anion-selective channels in planar lipid bilayer membranes, and we suggest that this channel-forming ability contributes to their antimicrobial properties observed in vitro.
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Citations
Cited by
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Self-citationAgents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism
Ibrahim, H. R., Sugimoto, Y., & Aoki, T. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00122-7 · Cited by 319
The Use of Therapeutic Peptides to Target and to Kill Cancer Cells
J. Boohaker, R., W. Lee, M., Vishnubhotla, P., M. Perez, J. L., & R. Khaled, A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801661004 · Cited by 302
Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores
Fluckinger, M., Haas, H., Merschak, P., Glasgow, B. J., & Redl, B. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3367-3372.2004 · Cited by 195
Discovery and development of a synthetic peptide derived from lactoferrin for clinical use
Brouwer, C. P. J. M., Rahman, M., & Welling, M. M. (2011) · Peptides · doi:10.1016/j.peptides.2011.07.017 · Cited by 90
Andrés, M. T., Fierro, P., Antuña, V., & Fierro, J. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137335 · Cited by 8
Metadata
- Authors
- Kagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-01
- Volume
- 87
- Issue
- 1
- Pages
- 210-214
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988441448
- Cited by
- 532
- References
- 0
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
