Discovery and development of a synthetic peptide derived from lactoferrin for clinical use
Abstract
There is an urgent need to develop new antimicrobial drugs especially for combating the rise of infections caused by multi-resistant pathogens such as MRSA and VRSA. The problem of antibiotic resistant micro-organisms is expected to increase disproportionally and controlling of infections is becoming difficult because of the rapid spread of those micro-organisms. Primary therapy with classical antibiotics is becoming more ineffective. Combinational therapy of antibiotics with antimicrobial peptides (AMP's) has been suggested as an alternative approach to improve treatment outcome. Their unique mechanism of action and safety profile makes AMP's appealing candidates for simultaneous or sequential use in different cases of infections. In this review, for antimicrobial treatment the application of synthetic antimicrobial peptide hLF(1-11), derived from the first 11 amino acids of human lactoferrin is evaluated in both pre-clinical and clinical settings. Present information indicates that this derivate from lactoferrin is well tolerated in pre-clinical tests and clinical trials and thus hLF(1-11) is an interesting candidate for further exploration in various clinical indications of obscure infections, including meningitis. Another approach of using AMP's is their use in prevention of infections e.g. as coating for dental or bone implants or in biosensing applications or useful as infection specific radiopharmaceutical.
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The human lactoferrin derived peptide was well tolerated in preclinical tests and clinical trials.
“The third group is formed by synthetic derived peptides, that is, the “human lactoferrin derived peptide” which was well tolerated in preclinical tests and clinical trials [56].”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [56]
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- Authors
- Brouwer, C. P. J. M., Rahman, M., & Welling, M. M.
- Affiliations
- Leiden University Medical Center (NL)
- NAEJA-RGM Pharmaceuticals (Canada) (CA)
- Corresponding author
- Brouwer, Carlo P.J.M.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 32
- Issue
- 9
- Pages
- 1953-1963
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2010946839
- Cited by
- 90
- References
- 146
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 11 · 2019: 3 · 2018: 2 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 6
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- antimicrobial peptides, lactoferrin, synthetic peptides, antibiotic resistance, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, combination antibiotic therapy, meningitis, implant infection prevention, biosensing, radiopharmaceuticals, clinical trials
- MeSH terms
- Amino Acid Sequence, Animals, Anti-Infective Agents, Bacterial Infections, Candida, Clinical Trials as Topic, Drug Evaluation, Drug Resistance, Microbial, Drug Synergism, Humans, Lactoferrin, Molecular Sequence Data, Mycoses, Peptide Fragments, Antimicrobial Cationic Peptides, Mice, Methicillin-Resistant Staphylococcus aureus, Drug Discovery, Chemistry Techniques, Synthetic
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