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A simple model for the immune network.
Open accessAbstract
In this note I present a simple model for the idiotypic network among antibodies and study its relevance for the maintenance of immunological memory; in particular, the memory capacity of such a model is studied. Some of the similarities with the spin glass model and with neural networks are discussed.
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“Interestingly, the basic McCulloch–Pitts design is common to many other living systems, including gene regulatory networks [256–259], immune networks [260–262], collective intelligence [263–267] or some aneural systems, such as quorum-sensing decisions in microbial communities, where an explicit equivalence has been defined [268].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [260]
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Metadata
- Authors
- Parisi, G.
- Affiliations
- Dipartimento di Fisica, Universita' di Roma II, Tor Vergata, Italy.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1990-01
- Volume
- 87
- Issue
- 1
- Pages
- 429-433
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC53277
- OpenAlex
- W1997967320
- Cited by
- 104
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Immune Systems Applications
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Physical Sciences › Computer Science › Artificial Intelligence › Neural Networks and Applications
- Keywords
- immune network model, idiotypic network, immunoglobulins, immunological memory, memory capacity, spin glass models, artificial neural networks
- MeSH terms
- Animals, Immune System, Immunoglobulin Idiotypes, Immunologic Memory, Mathematics, Models, Biological, Models, Neurological, Neurons
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