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The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.
Open accessAbstract
We have examined the effect of different growth conditions on the ability of Salmonella to interact with Madin-Darby canine kidney cells. Two growth conditions that affect the expression of Salmonella adherence and invasiveness have been identified. First, bacteria lose their invasiveness in the stationary phase of growth. Second, bacteria growing in oxygen-limited growth conditions are induced for adherence and invasiveness, whereas those growing aerobically are relatively nonadherent and noninvasive. Salmonella from cultures aerated with gas mixtures containing 0% or 1% oxygen were 6- to 70-fold more adherent and invasive than those from cultures aerated with a gas mixture containing 20% oxygen. The Salmonella typhimurium oxrA gene that is required for the anaerobic induction of many proteins is not involved in the regulation of Salmonella invasiveness. We speculate that oxygen limitation might be an environmental cue that triggers the expression of Salmonella invasiveness within the intestinal lumen and other tissues.
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Citations
Cited by
Environmental signals controlling expression of virulence determinants in bacteria
Mekalanos, J. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.1.1-7.1992 · Cited by 788
Molecular genetic bases of Salmonella entry into host cells
Galán, J. E. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02615.x · Cited by 435
Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa
Darwin, K. H., & Miller, V. L. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.3.405 · Cited by 435
Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J.-P., & Sirard, J.-C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241308598 · Cited by 368
Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants
Lee, C. A., Jones, B. D., & Falkow, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1847 · Cited by 296
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Metadata
- Authors
- Lee, C. A., & Falkow, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 11
- Pages
- 4304-4308
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2054440815
- Cited by
- 459
- References
- 0
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, C. A., & Falkow, S. (1990). The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.11.4304
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