The DOI matches its Crossref record.
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Open accessAbstract
We have isolated a common insertion site, Wnt-3, for proviruses of the mouse mammary tumor virus (MMTV). Of mammary tumors induced by the GR variant of MMTV, 5% contains a provirus at Wnt-3, which is located on mouse chromosome 11. The gene is transcribed into a 3.8-kilobase (kb) mRNA in tumors with nearby proviral insertions but not in tumors with proviruses at other loci or in most adult tissues. Normal expression of Wnt-3 is detected in mouse embryos (with a peak around day 12 of gestation) and at low levels in adult brain. The transcriptional unit of the Wnt-3 gene spans approximately 55 kb, with a first intron of 36 kb. The deduced amino acid sequence of the Wnt-3 protein is 47% identical to the int-1/Wnt-1 gene product.
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Cited by
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,520
Lin, S.-Y., Xia, W., Wang, J. C., Kwong, K. Y., Spohn, B., Wen, Y., Pestell, R. G., & Hung, M.-C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060025397 · Cited by 783
McMahon, A. P., Joyner, A. L., Bradley, A., & McMahon, J. A. (1992) · Cell · doi:10.1016/0092-8674(92)90222-x · Cited by 584
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
Metadata
- Authors
- Roelink, H., Wagenaar, E., Lopes da Silva, S., & Nusse, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 12
- Pages
- 4519-4523
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2086028819
- Cited by
- 187
- References
- 0
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. https://app.cochat.ai/papers/10.1073/pnas.87.12.4519
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- Roelink, H., Wagenaar, E., Lopes da Silva, S., & Nusse, R. (1990). Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.12.4519
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