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Polymer−Peptide Conjugates Convert Amyloid into Protein Nanobundles through Fragmentation and Lateral Association

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Dynamics of the conformational transitions during the dimerization of an intrinsically disordered peptide: a case study on the human islet amyloid polypeptide fragment

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Physico-chemical stability of co-formulation of PEGylated human amylin with insulin

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Cell surface glycosaminoglycans exacerbate plasma membrane perturbation induced by the islet amyloid polypeptide

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Amyloidogenicity of peptides targeting diabetes and obesity

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Evolutionary Adaptation and Amyloid Formation: Does the Reduced Amyloidogenicity and Cytotoxicity of Ursine Amylin Contribute to the Metabolic Adaption of Bears and Polar Bears?

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Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore

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Conformational polymorphism and cellular toxicity of IAPP and βAP domains

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Amylin and diabetic cardiomyopathy – amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium

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Molecular Mechanisms of Fibrillogenesis and the Protective Role of Amyloid P Component: Two Possible Avenues for Therapy

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Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation

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RNA-seq-based identification of Star upregulation by islet amyloid formation

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Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry

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Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

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The binding of synthetic triiodo l-thyronine analogs to human transthyretin: Molecular basis of cooperative and non-cooperative ligand recognition

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Human Islet Amyloid Polypeptide Assembly: The Key Role of the 8–20 Fragment

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Studies of variability in the islet amyloid polypeptide gene in relation to Type 2 diabetes

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4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

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Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy

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Ferret islet amyloid polypeptide (IAPP): characterization ofin vitroandin vivoamyloidogenicity

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Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe

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Structural Modulation of Human Amylin Protofilaments by Naturally Occurring Mutations

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γ-AApeptides–based Small Molecule Ligands That Disaggregate Human Islet Amyloid Polypeptide

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Scaffolded multimers of hIAPP20–29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20–29 peptide fragment

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Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

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Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

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Understanding the structural dynamics of human islet amyloid polypeptide: Advancements in and applications of ion-mobility mass spectrometry

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Human Islet Amyloid Polypeptide Fibril Binding to Catalase: A Transmission Electron Microscopy and Microplate Study

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Complete characterization of the mutation landscape reveals the effect on amylin stability and amyloidogenicity

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Loss of perlecan heparan sulfate glycosaminoglycans lowers body weight and decreases islet amyloid deposition in human islet amyloid polypeptide transgenic mice

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Influence of force field choice on the conformational landscape of rat and human islet amyloid polypeptide

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Rapid, scalable assay of amylin-β amyloid co-aggregation in brain tissue and blood

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Noncore Residues Influence the Kinetics of Functional TTR105–115-Based Amyloid Fibril Assembly

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Be positive: optimizing pramlintide from microcanonical analysis of amylin isoforms

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From Peptide Fragments to Whole Protein: Copper(II) Load and Coordination Features of IAPP

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All‐atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints

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The toxic nature of murine amylin and the immune responsivity of pancreatic islet to conformational antibody in mice

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Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

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Amyloidogenesis of feline amylin and plasma levels in cats with diabetes mellitus or pancreatitis

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Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro

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The Use of Chromogranin, Synaptophysin and Islet Amyloid Polypeptide as Markers for Neuroendocrine Tumours

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Amyloidogenicity and cytotoxicity of des-Lys-1 human amylin provides insight into amylin self-assembly and highlights the difficulties of defining amyloidogenicity

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Amylin

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Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice

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Historical Background

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Chapter 9. Endogenous Vasoactive Peptides

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Inhibition of the Early-Stage Cross-Amyloid Aggregation of Amyloid‑β and IAPP via EGCG: Insights from Molecular Dynamics Simulations

Srivastava, A., Adem, K. A., Shanti, A., Lee, S., Abedrabbo, S. M., & Homouz, D. (2024) · ACS Omega · doi:10.1021/acsomega.4c00500 · Cited by 11

Central nervous system pathways targeted by amylin in the regulation of food intake

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Structural and thermodynamical properties of early human amylin oligomers using replica exchange molecular dynamics: mutation effect of three key residues F15, H18 and F23

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Sequence-dependent aggregation-prone conformations of islet amyloid polypeptide

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Human Amylin in the Presence of SARS-COV-2 Protein Fragments

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Phytoconstituents of Ashwagandha as potential inhibitors of human islet amyloid polypeptide (hIAPP): an in silico investigation

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Oxidative Modification, Inflammation and Amyloid in the Normal and Diabetic Cat Pancreas

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Amylin reduces plasma glucagon concentration in cats

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Influence of the Human and Rat Islet Amyloid Polypeptides on Structure of Phospholipid Bilayers: Neutron Reflectometry and Fluorescence Microscopy Studies

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Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro

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Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice

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Influence of human amylin on the membrane stability of rat primary hippocampal neurons

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Human amylin mimicks amyloid β protein-induced reactive gliosis and inhibition of cellular redox activity in cultured astrocytes

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Sequence of raccoon IAPP supports importance of a specific structural motif in the development of pancreatic islet amyloidosis

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Chapter viii calcitonin gene-related peptide (cgrp), amylin and adrenomedullin: anatomical localization and biological functions in the mammalian and human brains

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Natural compound plumbagin based inhibition of hIAPP revealed by Markov state models based on MD data along with experimental validations

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The dye SYPRO orange binds to amylin amyloid fibrils but not pre‐fibrillar intermediates

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Formation of lamellar micelle-like oligomers and membrane disruption revealed by the study of short peptide hIAPP 18–27

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Stabilization Effect of Amino Acid Side Chains in Peptide Assemblies on Graphite Studied by Scanning Tunneling Microscopy

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Exploring the relation between the oligomeric structure and membrane damage by a study on rat islet amyloid polypeptide

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Oligotyrosines Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in a Tyrosine-Number-Dependent Manner

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