Betsholtz, Christer

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 3,124

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology

Angiogenesis and VEGF in CancerAxon Guidance and Neuronal Signaling

Cited by 2,894

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 2,843

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell

Barrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

Cited by 2,653

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science

Barrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

Cited by 2,226

Endothelial/Pericyte Interactions

Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 2,048

A molecular atlas of cell types and zonation in the brain vasculature

Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 1,892

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature

Angiogenesis and VEGF in CancerDevelopmental Biology and Gene Regulation

Cited by 1,775

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 1,670

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 1,293

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

Gaengel, K., Genové, G., Armulik, A., & Betsholtz, C. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 933

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 866

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell

Neonatal Respiratory Health ResearchInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 864

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

Westermark, P., Engström, U., Johnson, K. H., Westermark, G. T., & Betsholtz, C. (1990) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsPancreatic function and diabetes

Cited by 807

Insight into the physiological functions of PDGF through genetic studies in mice

Betsholtz, C. (2004) · Cytokine & Growth Factor Reviews

Liver physiology and pathologyFibroblast Growth Factor Research

Cited by 437

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

He, L., Vanlandewijck, M., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Scientific Data

Single-cell and spatial transcriptomicsAngiogenesis and VEGF in Cancer

Cited by 413

Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin

Pekny, M., Johansson, C. B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H., & Frisén, J. (1999) · The Journal of Cell Biology

Spinal Cord Injury ResearchSkin and Cellular Biology Research

Cited by 405

Intermediate Filament Protein Partnership in Astrocytes

Eliasson, C., Sahlgren, C., Berthold, C.-H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E., & Pekny, M. (1999) · Journal of Biological Chemistry

Skin and Cellular Biology ResearchConnexins and lens biology

Cited by 357

Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.

Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C. H., Westermark, B., & Betsholtz, C. (1995) · The EMBO Journal

Skin and Cellular Biology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 336

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., Lemos, R. R., Ordoñez-Ugalde, A., Nicolas, G., da Cunha, J. E. G., et al. (2013) · Nature Genetics

Neurological diseases and metabolismNeurological and metabolic disorders

Cited by 324

Specification of CNS macrophage subsets occurs postnatally in defined niches

Masuda, T., Amann, L., Monaco, G., Sankowski, R., Staszewski, O., Krueger, M., Del Gaudio, F., He, L., Paterson, N., Nent, E., et al. (2022) · Nature

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 294

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases

Franzén, O., Ermel, R., Cohain, A., Akers, N. K., Di Narzo, A., Talukdar, H. A., Foroughi-Asl, H., Giambartolomei, C., Fullard, J. F., Sukhavasi, K., et al. (2016) · Science

Genetic Associations and EpidemiologyNutrition, Genetics, and Disease

Cited by 288

Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Li, X., Eriksson, U., & Pietras, K. (2009) · Cancer Research

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 249

A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures

Rymo, S. F., Gerhardt, H., Wolfhagen Sand, F., Lang, R., Uv, A., & Betsholtz, C. (2011) · PLoS ONE

Angiogenesis and VEGF in CancerNeuroinflammation and Neurodegeneration Mechanisms

Cited by 235