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Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.
Open accessAbstract
Pneumocystis carinii pneumonia is a major cause of death in AIDS patients in the United States. The presently available treatments have limited use due to a high incidence of adverse reactions. Therefore, there is an urgent need for a safer method for treatment and prevention of this disease. Recent evidence has suggested that P. carinii is related to fungi and that the wall of the cyst form contains 1,3-beta-glucan as a major constituent. Based on this, several proposed 1,3-beta-glucan synthesis inhibitors were evaluated for their ability to control P. carinii pneumonia in vivo. Compounds from two classes of 1,3-beta-glucan synthesis inhibitors, the echinocandins and papulacandins, were found to be effective against P. carinii.
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Cited by
Antifungal agents: chemotherapeutic targets and immunologic strategies
Georgopapadakou, N. H., & Walsh, T. J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.279 · Cited by 498
Colonization by Pneumocystis jirovecii and Its Role in Disease
Morris, A., & Norris, K. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-12 · Cited by 429
Groll, A. H., Piscitelli, S. C., & Walsh, T. J. (1998) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60129-5 · Cited by 377
Kurtz, M. B., Heath, I. B., Marrinan, J., Dreikorn, S., Onishi, J., & Douglas, C. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.7.1480 · Cited by 320
Fishman, J. A., Gans, H., & Practice, T. A. I. D. C. O. (2019) · Clinical Transplantation · doi:10.1111/ctr.13587 · Cited by 293
Metadata
- Authors
- Schmatz, D. M., Romancheck, M. A., Pittarelli, L. A., Schwartz, R. E., Fromtling, R. A., Nollstadt, K. H., Vanmiddlesworth, F. L., Wilson, K. E., & Turner, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-08
- Volume
- 87
- Issue
- 15
- Pages
- 5950-5954
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063640981
- Cited by
- 161
- References
- 0
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Schmatz, D. M., Romancheck, M. A., Pittarelli, L. A., Schwartz, R. E., Fromtling, R. A., Nollstadt, K. H., Vanmiddlesworth, F. L., Wilson, K. E., & Turner, M. J. (1990). Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.15.5950
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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