The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Open accessAbstract
Small cell lung cancer (SCLC) is a fatal malignancy due to its propensity to metastasize widely and to reoccur after chemotherapy in a drug-resistant form. While most SCLC cell lines are anchorage independent for growth, laminin induced the attachment of five of six SCLC cell lines tested (NCI-N417, NCI-H345, NCI-H146, NCI-H187, NCI-H510, and NCI-H209). NCI-N417 SCLC cells adopted a flattened morphology on laminin, and a classic SCLC cell line (NCI-H345) demonstrated a neuron-like appearance while the other SCLC cell lines except NCI-H187 cells, attached but did not spread. Adhesion to laminin was associated with increased resistance to several cytotoxic drugs. Matrigel, an extract of basement membrane proteins, greatly accelerated tumor growth when coinjected with SCLC cells in athymic mice. A synthetic peptide from the B1 chain of laminin, cyclic-YIGSR (Tyr-Ile-Gly-Ser-Arg), inhibited laminin-induced SCLC cell adhesion and migration in vitro and reduced the size of the tumors they formed when coinjected with matrigel and YIGSR. These results suggest that the interaction of SCLC cells with laminin and possibly with other basement membrane proteins can enhance their tumorigenicity and drug resistance.
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Cites
Carmichael, J., DeGraff, W., Gazdar, A. F., Minna, J. D., & Mitchell, J. B. (1987) · PubMed · Cited by 3,813
Self-citationBasement membrane complexes with biological activity
Kleinman, H. K., McGarvey, M. L., Hassell, J. R., Star, V. L., Cannon, F. B., Laurie, G. W., & Martin, G. R. (1986) · Biochemistry · doi:10.1021/bi00350a005 · Cited by 1,502
Self-citationKleinman, H. K., McGarvey, M. L., Liotta, L. A., Robey, P. G., Tryggvason, K., & Martin, G. R. (1982) · Biochemistry · doi:10.1021/bi00267a025 · Cited by 1,231
Self-citation(1986) · Lung Cancer · doi:10.1016/s0169-5002(86)80023-x · Cited by 900
BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE
Liotta, L. A., Nageswara Rao, C. N., & Wewer, U. M. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.005133 · Cited by 693
Graf, J., Iwamoto, Y., Sasaki, M., Martin, G. R., Kleinman, H. K., Robey, F. A., & Yamada, Y. (1987) · Cell · doi:10.1016/0092-8674(87)90707-0 · Cited by 671
Self-citationGazdar, A. F., Carney, D. N., Nau, M. M., & Minna, J. D. (1985) · PubMed · Cited by 477
Self-citationRole of laminin in the attachment and metastasis of murine tumor cells.
Terranova, V. P., Liotta, L. A., Russo, R. G., & Martin, G. R. (1982) · PubMed · Cited by 335
Self-citationLaminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro.
McCarthy, J. B., & Furcht, L. T. (1984) · The Journal of cell biology · doi:10.1083/jcb.98.4.1474 · Cited by 314
Modulation of the Metastatic Activity of Melanoma Cells by Laminin and Fibronectin
Terranova, V. P., Williams, J. E., Liotta, L. A., & Martin, G. R. (1984) · Science · doi:10.1126/science.6505678 · Cited by 256
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Bachem, M. G., Schünemann, M., Ramadani, M., Siech, M., Beger, H., Buck, A., Zhou, S., Schmid-Kotsas, A., & Adler, G. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.036 · Cited by 657
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Micke, P., & tman, A. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.07.977 · Cited by 344
Metadata
- Authors
- Fridman, R., Giaccone, G., Kanemoto, T., Martin, G. R., Gazdar, A. F., & Mulshine, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-09
- Volume
- 87
- Issue
- 17
- Pages
- 6698-6702
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063599502
- Cited by
- 255
- References
- 16
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines. https://app.cochat.ai/papers/10.1073/pnas.87.17.6698
- The paper
- Fridman, R., Giaccone, G., Kanemoto, T., Martin, G. R., Gazdar, A. F., & Mulshine, J. L. (1990). Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.17.6698
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
