Environment-mediated drug resistance: A major contributor to minimal residual disease
Abstract
Environment-mediated drug resistance is a form of de novo drug resistance that protects tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can then develop complex and permanent acquired resistance in response to the selective pressure of therapy. Recent evidence indicates that environment-mediated drug resistance arises from an adaptive, reciprocal signalling dialogue between tumour cells and the surrounding microenvironment. We propose that new therapeutic strategies targeting this interaction should be applied during initial treatment to prevent the emergence of acquired resistance.
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Bidirectional communication between tumor cells and the stroma triggers protective signaling cascades, contributing to Environment-Mediated Drug Resistance (EMDR).
“Bidirectional communication between tumor cells and the stroma triggers protective signaling cascades, contributing to what is termed Environment-Mediated Drug Resistance (EMDR) [143].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [143]
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- Authors
- Meads, M. B., Gatenby, R. A., & Dalton, W. S.
- Affiliations
- Moffitt Cancer Center (US)
- Corresponding author
- Dalton, William S.
- Venue
- Nature Reviews Cancer
- Published
- 2009-08-20
- Volume
- 9
- Issue
- 9
- Pages
- 665-674
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2066616821
- Cited by
- 892
- References
- 109
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 35 · 2023: 55 · 2022: 54 · 2021: 74 · 2020: 65 · 2019: 58 · 2018: 56 · 2017: 52 · 2016: 68 · 2015: 61 · 2014: 64 · 2013: 51 · 2012: 52
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- tumor microenvironment, minimal residual disease, recurrence, acquired drug resistance, stromal factors, adjuvant therapy, cancer therapy resistance
- MeSH terms
- Humans, Neoplasms, Signal Transduction, Stromal Cells, Neoplasm, Residual, Drug Resistance, Neoplasm
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