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Cited by 358

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

Open access
Matsumoto, A, Naito, M, Itakura, H, Ikemoto, S, Asaoka, H, Hayakawa, I, Kanamori, H, Aburatani, H, Takaku, F, Suzuki, H·1990·Proceedings of the National Academy of Sciences

Abstract

Two types of cDNAs for human macrophage scavenger receptors were cloned from a cDNA library derived from the phorbol ester-treated human monocytic cell line THP-1. The type I and type II human scavenger receptors encoded by these cDNAs are homologous (73% and 71% amino acid identity) to their previously characterized bovine counterparts and consist of six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V), and a type-specific C-terminal (VI). The receptor gene is located on human chromosome 8. The human receptors expressed in CHO-K1 cells mediated endocytosis of modified low density lipoproteins. Two mRNAs, 4.0 and 3.2 kilobases, have been detected in human liver, placenta, and brain. Immunohistochemical studies using an anti-peptide antibody which recognizes human scavenger receptors indicated the presence of the scavenger receptors in the macrophages of lipid-rich atherosclerotic lesions, suggesting the involvement of scavenger receptors in atherogenesis.

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Crossref · 10.1073/pnas.87.23.9133

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Metadata

Authors
Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H., Aburatani, H., Takaku, F., & Suzuki, H.
Venue
Proceedings of the National Academy of Sciences
Published
1990-12
Volume
87
Issue
23
Pages
9133-9137
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2058060182
Cited by
358
References
1
FWCI
25.57
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. https://app.cochat.ai/papers/10.1073/pnas.87.23.9133
The paper
Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H., Aburatani, H., Takaku, F., & Suzuki, H. (1990). Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.23.9133

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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