The DOI matches its Crossref record.
Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
Open accessAbstract
Characterization of the polypeptides present in bone-inductive protein extracts from bovine bone has led to the cloning of seven regulatory molecules, six of which are distantly related to transforming growth factor beta. The three human bone morphogenetic proteins (BMPs) we describe herein, BMP-5, BMP-6, and BMP-7, show extensive sequence similarity to BMP-2, a molecule that by itself is sufficient to induce de novo bone formation in vivo. The additive or synergistic contribution of these BMP-2-related molecules to the osteogenic activity associated with demineralized bone is strongly implicated by the presence of these growth factors in the most active fractions of highly purified bone extract.
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Citations
Cited by
OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism
Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724
Psychosocial Aspects of Disabling Musculoskeletal Pain
Vranceanu, A.-M., Barsky, A., & Ring, D. (2009) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/jbjs.h.01512 · Cited by 304
New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
Saito, N., & Takaoka, K. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00040-1 · Cited by 153
Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., & Lee, S.-J. (1995) · Growth Factors · doi:10.3109/08977199509028956 · Cited by 104
Bergeron, E., Leblanc, E., Drevelle, O., Giguère, R., Beauvais, S., Grenier, G., & Faucheux, N. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0008 · Cited by 51
Metadata
- Authors
- Celeste, A. J., Iannazzi, J. A., Taylor, R. C., Hewick, R. M., Rosen, V, Wang, E. A., & Wozney, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-12
- Volume
- 87
- Issue
- 24
- Pages
- 9843-9847
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975828859
- Cited by
- 826
- References
- 0
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. https://app.cochat.ai/papers/10.1073/pnas.87.24.9843
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- Celeste, A. J., Iannazzi, J. A., Taylor, R. C., Hewick, R. M., Rosen, V, Wang, E. A., & Wozney, J. M. (1990). Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.24.9843
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