The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.
Open accessAbstract
The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of TNF-alpha were assessed on three levels: (i) insulitis development, (ii) development of overt diabetes, (iii) adoptive transfer of diabetes by splenic lymphocytes. Spontaneous diabetes mellitus was blocked in NOD mice by long-term treatment with recombinant TNF-alpha. Treatment with TNF-alpha caused a significant reduction in the lymphocytic infiltration associated with the destruction of the insulin-producing beta cells. Class II major histocompatibility complex Ia expression by islet cells was not up-regulated by TNF-alpha. Moreover, TNF-alpha was able to suppress the induction of diabetes in adoptive transfer of lymphocytes from diabetic female mice to young nondiabetic male NOD mice. These activities of TNF-alpha were shared by interleukin 1 alpha in this system. These studies have implications for the pathogenesis and therapy of autoimmune diabetes mellitus.
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Self-citationCytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans
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Cited by
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
The role of interleukin-1 in the pathogenesis of IDDM
Mandrup-Poulsen, T. (1996) · Diabetologia · doi:10.1007/bf00400649 · Cited by 543
Rabinovitch, A., & Suarez-Pinzon, W. L. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00492-9 · Cited by 466
A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation
Shoda, L. K. M., Young, D. L., Ramanujan, S., Whiting, C. C., Atkinson, M. A., Bluestone, J. A., Eisenbarth, G. S., Mathis, D., Rossini, A. A., Campbell, S. E., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.002 · Cited by 317
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling
Cope, A. P., Liblau, R. S., Yang, X.-D., Congia, M., Laudanna, C., Schreiber, R. D., Probert, L., Kollias, G., & McDevitt, H. O. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1573 · Cited by 287
Self-citation
Metadata
- Authors
- Jacob, C. O., Aiso, S., Michie, S. A., McDevitt, H. O., & Acha-Orbea, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-02
- Volume
- 87
- Issue
- 3
- Pages
- 968-972
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012487047
- Cited by
- 349
- References
- 24
- FWCI
- 18.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Jacob, C. O., Aiso, S., Michie, S. A., McDevitt, H. O., & Acha-Orbea, H. (1990). Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.3.968
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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